Journal article
Enzymatically prepared poly(hydroquinone) as a mediator for amperometric glucose sensors
Polymer (Guilford), Vol.39(1), pp.123-127
1998
DOI: 10.1016/S0032-3861(97)00228-0
Abstract
Poly(hydroquinone) (PHQ), synthesized from glucose-β-
d-hydroquinone by peroxidase-catalyzed polymerization in aqueous solution and placed on glassy carbon electrodes, behaves as a redox mediator for glucose sensing. The highly selective nature of enzymatic catalysis leads to PHQ with a unique structure which is more soluble in organic solvents and more electrochemically active, as compared to that prepared via electrochemical methods. A glucose sensor is constructed in a pellet form with PHQ, glucose oxidase (GOD) and graphite powder. PHQ retains its redox activity and reversibility in the solid state and effectively mediates the electron transfer between the electrode and GOD. Resulting glucose biosensors possess sub-minute response times over a dynamic range from 1 to 30 mM. The PHQ mediator permits sensor operation at 100 mV (versus SCE), thereby reducing susceptibility toward common endogenous, easily oxidizable interferences.
Details
- Title: Subtitle
- Enzymatically prepared poly(hydroquinone) as a mediator for amperometric glucose sensors
- Creators
- Ping Wang - Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, IA 52242, USASudath Amarasinghe - Department of Chemistry, University of Iowa, Iowa City IA 52242, USAJohna Leddy - Department of Chemistry, University of Iowa, Iowa City IA 52242, USAMark Arnold - Department of Chemistry, University of Iowa, Iowa City IA 52242, USAJonathan S Dordick - Department of Chemical and Biochemical Engineering, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Polymer (Guilford), Vol.39(1), pp.123-127
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/S0032-3861(97)00228-0
- ISSN
- 0032-3861
- eISSN
- 1873-2291
- Language
- English
- Date published
- 1998
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Center for Biocatalysis and Bioprocessing; Chemistry
- Record Identifier
- 9984216674902771
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