Journal article
Enzyme-Transporter-Mediated Drug Interactions with Small Molecule Tyrosine Kinase Inhibitors
Journal of pharmaceutical sciences, Vol.103(12), pp.3810-3833
12/2014
DOI: 10.1002/jps.24113
PMID: 25308414
Abstract
Among the novel and target-specific classes of anticancer drugs, small molecule tyrosine kinase inhibitors (TKIs) represent an extremely promising and rapidly expanding group. TKIs attack cancer-specific targets and therefore have a favorable safety profile. However, as TKIs are taken orally along with other medications on a daily basis, there is an elevated risk of potentially significant drug–drug interactions. Most TKIs are metabolized primarily through CYP3A4. In addition, many TKIs are also CYP3A4 inhibitors at the same time. In addition to drug metabolizing enzymes (DMEs), another determinant of TKI disposition are drug transporters. There is accumulating evidence showing that the majority of currently marketed TKIs interact with ATP-binding cassette transporters, particularly P-glycoprotein as well as Breast Cancer Resistance Protein and serve as both substrates and inhibitors. Considering the dual roles of TKIs on both DMEs and drug transporters, and the importance of these enzyme and transporters in drug disposition, the potential for enzyme- and transporter-mediated TKI–drug interactions in patients with cancer is an important consideration. This review provides a comprehensive overview of drug interactions with small molecule TKIs mediated by DMEs and drug transporters. The TKI–drug interactions with TKIs being victims and/or perpetrators are summarized. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:3810–3833, 2014
Details
- Title: Subtitle
- Enzyme-Transporter-Mediated Drug Interactions with Small Molecule Tyrosine Kinase Inhibitors
- Creators
- Jie Shao - Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FloridaJohn S Markowitz - Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FloridaDi Bei - Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FloridaGuohua An - Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, Florida
- Resource Type
- Journal article
- Publication Details
- Journal of pharmaceutical sciences, Vol.103(12), pp.3810-3833
- DOI
- 10.1002/jps.24113
- PMID
- 25308414
- NLM abbreviation
- J Pharm Sci
- ISSN
- 0022-3549
- eISSN
- 1520-6017
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 12/2014
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984065315502771
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