Journal article
Eosinophilic esophagitis: current perspectives from diagnosis to management
Annals of the New York Academy of Sciences, Vol.1380(1), pp.204-217
09/2016
DOI: 10.1111/nyas.13164
PMID: 27467185
Abstract
Eosinophilic esophagitis (EoE) is a chronic antigen-mediated immune disease of the esophagus characterized by symptoms related to esophageal dysfunction, as well as significant esophageal eosinophilia. Although dense eosinophilia is the hallmark of EoE, other characteristic histologic features have been described that may help distinguish EoE from other competing diagnoses, although none are specific to EoE. One or more foods and, at times, environmental allergens trigger EoE. Left untreated, esophageal inflammation in EoE may lead to esophageal remodeling and stricture formation. Symptoms in EoE vary with age, as they relate to the progression of the disease from an inflammatory to a fibrostenotic phenotype over time. There are currently no U.S. Food and Drug Administration-approved therapies for EoE. Current options include various dietary-restriction therapies, topical corticosteroids, and esophageal dilations. Several emerging therapies aiming at restoring the esophageal barrier function or targeting various inflammatory cells or their mediators are under investigation.
Details
- Title: Subtitle
- Eosinophilic esophagitis: current perspectives from diagnosis to management
- Creators
- Fouad J Moawad - Gastroenterology Service, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland. fmoawad@hotmail.comEdaire Cheng - Pediatric Gastroenterology, Hepatology & Nutrition Division, University of Texas Southwestern Medical Center, Dallas, TexasAlain Schoepfer - Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire, Vaudois/CHUV, Lausanne, SwitzerlandSahar Al-Haddad - Department of Laboratory Medicine, St. Michael's Hospital, Hamilton, Ontario, CanadaAndrew M Bellizzi - Department of Pathology, University of Iowa Hospitals and Clinics, University of Iowa Carver College of Medicine, Iowa City, IowaHeather Dawson - Institute of Pathology, University of Bern, Bern, SwitzerlandHala El-Zimaity - Ontario Dynacare Laboratories, Ontario, CanadaMaha Guindi - Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CaliforniaRoberto Penagini - Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, and Department of Pathophysiology and Transplantation, Università degli Studi, Milan, ItalyEkaterina Safrooneva - Institute of Social and Preventive Medicine, University of Bern, Bern, SwitzerlandMirna Chehade - Department of Pediatrics and Medicine, Mount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai, New York, New York
- Resource Type
- Journal article
- Publication Details
- Annals of the New York Academy of Sciences, Vol.1380(1), pp.204-217
- DOI
- 10.1111/nyas.13164
- PMID
- 27467185
- NLM abbreviation
- Ann N Y Acad Sci
- ISSN
- 0077-8923
- eISSN
- 1749-6632
- Publisher
- Wiley; United States
- Language
- English
- Date published
- 09/2016
- Academic Unit
- Pathology
- Record Identifier
- 9984047732702771
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