Journal article
Eosinophils and mast cells in leishmaniasis
Immunologic research, Vol.59(1-3), pp.129-141
08/2014
DOI: 10.1007/s12026-014-8536-x
PMCID: PMC5106292
PMID: 24838146
Abstract
Leishmania spp. are parasitic protozoa endemic in tropical and subtropical regions and the causative agent of leishmaniasis, a collection of syndromes whose clinical manifestations vary according to host and pathogen factors. Leishmania spp. are inoculated into the mammalian host by the bite of an infected sand fly, whereupon they are taken up by phagocytosis, convert into the replicative amastigote stage within macrophages, reproduce, spread to new macrophages and cause disease manifestations. A curative response against leishmaniasis depends in the classical activation of macrophages and the IL-12-dependent onset of an adaptive type 1 response characterized by the production of IFN-γ. Emerging evidence suggests that neutrophils, dendritic cells and other immune cells can serve as either temporary or stable hosts for Leishmania spp. Furthermore, it is becoming apparent that the initial interactions of the parasite with resident or early recruited immune cells can shape both the macrophage response and the type of adaptive immune response being induced. In this review, we compile a growing number of studies demonstrating how the earliest interactions of Leishmania spp. with eosinophils and mast cells influence the macrophage response to infection and the development of the adaptive immune response, hence, determining the ultimate outcome of infection.
Details
- Title: Subtitle
- Eosinophils and mast cells in leishmaniasis
- Creators
- Nilda E Rodríguez - Department of Biology, University of Northern Iowa, Cedar Falls, IA, USA, nilda.rodriguez@uni.eduMary E Wilson
- Resource Type
- Journal article
- Publication Details
- Immunologic research, Vol.59(1-3), pp.129-141
- DOI
- 10.1007/s12026-014-8536-x
- PMID
- 24838146
- PMCID
- PMC5106292
- NLM abbreviation
- Immunol Res
- ISSN
- 0257-277X
- eISSN
- 1559-0755
- Publisher
- United States
- Grant note
- R01 AI045540 / NIAID NIH HHS R01 AI048822 / NIAID NIH HHS R01 AI076233 / NIAID NIH HHS I01 BX001983 / BLRD VA I01 BX000536 / BLRD VA
- Language
- English
- Date published
- 08/2014
- Academic Unit
- Microbiology and Immunology; International Programs; Epidemiology; Internal Medicine
- Record Identifier
- 9984001208802771
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