Journal article
Ependymoma: Results, Prognostic Factors and Treatment Recommendations
International journal of radiation oncology, biology, physics, Vol.40(4), pp.845-850
1998
DOI: 10.1016/S0360-3016(97)00893-6
PMID: 9531369
Abstract
Purpose: To review the University of Florida experience in treating ependymomas, analyze prognostic factors, and provide treatment recommendations.
Methods and Materials: Forty-one patients with ependymoma and no metastases outside the central nervous system received postoperative radiotherapy with curative intent between 1966 and 1989. Ten patients had supratentorial lesions, 22 had infratentorial lesions, and 9 had spinal cord lesions. All patients had surgery (stereotactic biopsy, subtotal resection, or gross total resection). Most patients with high-grade lesions received radiotherapy to the craniospinal axis. Low-grade intracranial lesions received more limited treatment. Spinal cord lesions were treated using either partial spine or whole spine fields.
Results: Of 32 intracranial tumors, 21 recurred, all at the primary site; no spinal cord tumors recurred. Overall 10-year survival rates were 51% (absolute) and 46% (relapse-free); by tumor site: spinal cord, 100%; infratentorial, 45%; supratentorial, 20% (
p = 0.002). On multivariate analysis, tumor site was the only factor that influenced absolute survival (
p = 0.0004); other factors evaluated included grade, gender, age, duration of symptoms, resection extent, primary tumor dose, treatment field extent, surgery-to–radiotherapy interval, and days under radiotherapy treatment.
Conclusions: Patients with supratentorial or infratentorial tumors receive irradiation, regardless of grade. Craniospinal-axis fields are used when spinal seeding is radiographically or pathologically evident. Spinal cord tumors are treated using localized fields to the primary site if not completely resected. Failure to control disease at the primary site remains the main impediment to cure.
Details
- Title: Subtitle
- Ependymoma: Results, Prognostic Factors and Treatment Recommendations
- Creators
- Mark P McLaughlin - Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USARobert B Marcus - Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USAJohn M Buatti - Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USAW.Mark McCollough - Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USAJ.Parker Mickle - Department of Neurosurgery, University of Florida College of Medicine, Gainesville, FL, USAAmos Kedar - Department of Pediatric/Hematology, University of Florida College of Medicine, Gainesville, FL, USABernard L Maria - Department of Pediatric Neuro-Oncology, University of Florida College of Medicine, Gainesville, FL, USARodney R Million - Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA
- Resource Type
- Journal article
- Publication Details
- International journal of radiation oncology, biology, physics, Vol.40(4), pp.845-850
- DOI
- 10.1016/S0360-3016(97)00893-6
- PMID
- 9531369
- NLM abbreviation
- Int J Radiat Oncol Biol Phys
- ISSN
- 0360-3016
- eISSN
- 1879-355X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1998
- Academic Unit
- Radiation Oncology; Neurosurgery; Otolaryngology
- Record Identifier
- 9984040375302771
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