Journal article
Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells
Nature Communications, Vol.4(1), pp.1438-1438
2013
DOI: 10.1038/ncomms2445
PMID: 23385583
Abstract
Hearing requires an optimal afferent innervation of sensory hair cells by spiral ganglion neurons in the cochlea. Here we report that complementary expression of ephrin-A5 in hair cells and EphA4 receptor among spiral ganglion neuron populations controls the targeting of type I and type II afferent fibres to inner and outer hair cells, respectively. In the absence of ephrin-A5 or EphA4 forward signalling, a subset of type I projections aberrantly overshoot the inner hair cell layer and invade the outer hair cell area. Lack of type I afferent synapses impairs neurotransmission from inner hair cells to the auditory nerve. By contrast, radial shift of type I projections coincides with a gain of presynaptic ribbons that could enhance the afferent signalling from outer hair cells. Ephexin-1, cofilin and myosin light chain kinase act downstream of EphA4 to induce type I spiral ganglion neuron growth cone collapse. Our findings constitute the first identification of an Eph/ephrin-mediated mutual repulsion mechanism responsible for specific sorting of auditory projections in the cochlea.
Details
- Title: Subtitle
- Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells
- Creators
- Jean DefournyAnne-Lise PoirrierFrancois LallemendSusana Mateo SanchezJakob NeefPierre VanderhaeghenEduardo SorianoChristiane Peuckert - Genetisk utvecklingsbiologiKlas Kullander - Genetisk utvecklingsbiologiBernd FritzschLaurent NguyenGustave MoonenTobias MoserBrigitte Malgrange
- Resource Type
- Journal article
- Publication Details
- Nature Communications, Vol.4(1), pp.1438-1438
- DOI
- 10.1038/ncomms2445
- PMID
- 23385583
- NLM abbreviation
- Nat Commun
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Language
- English
- Date published
- 2013
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070389002771
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