Journal article
Epicardial adipose tissue has a unique transcriptome modified in severe coronary artery disease
Obesity (Silver Spring, Md.), Vol.23(6), pp.1267-1278
06/2015
DOI: 10.1002/oby.21059
PMCID: PMC5003780
PMID: 25959145
Abstract
To explore the transcriptome of epicardial adipose tissue (EAT) as compared to subcutaneous adipose tissue (SAT) and its modifications in a small number of patients with coronary artery disease (CAD) versus valvulopathy.
SAT and EAT samples were obtained during elective cardiothoracic surgeries. The transcriptome of EAT was evaluated, as compared to SAT, using an unbiased, whole-genome approach in subjects with CAD (n = 6) and without CAD (n = 5), where the patients without CAD had cardiac valvulopathy.
Relative to SAT, EAT is a highly inflammatory tissue enriched with genes involved in endothelial function, coagulation, immune signaling, potassium transport, and apoptosis. EAT is lacking in expression of genes involved in protein metabolism, tranforming growth factor-beta (TGF-beta) signaling, and oxidative stress. Although underpowered, in subjects with severe CAD, there is an expression trend suggesting widespread downregulation of EAT encompassing a diverse group of gene sets related to intracellular trafficking, proliferation/transcription regulation, protein catabolism, innate immunity/lectin pathway, and ER stress.
The EAT transcriptome is unique when compared to SAT. In the setting of CAD versus valvulopathy, there is possible alteration of the EAT transcriptome with gene suppression. This pilot study explores the transcriptome of EAT in CAD and valvulopathy, providing new insight into its physiologic and pathophysiologic roles.
Details
- Title: Subtitle
- Epicardial adipose tissue has a unique transcriptome modified in severe coronary artery disease
- Creators
- Elizabeth A McAninch - Department of Medicine, Division of Endocrinology and Metabolism, Rush University Medical Center, Chicago, Illinois, USATatiana L Fonseca - Department of Medicine, Division of Endocrinology and Metabolism, Rush University Medical Center, Chicago, Illinois, USARaffaella Poggioli - Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, Florida, USAAnthony L Panos - Department of Surgery, Division of Thoracic and Cardiac Surgery, University of Miami Miller School of Medicine, Miami, Florida, USATomas A Salerno - Department of Surgery, Division of Thoracic and Cardiac Surgery, University of Miami Miller School of Medicine, Miami, Florida, USAYouping Deng - Department of Medicine, Rush University Medical Center, Chicago, Illinois, USAYan Li - Department of Medicine, Rush University Medical Center, Chicago, Illinois, USAAntonio C Bianco - Department of Medicine, Division of Endocrinology and Metabolism, Rush University Medical Center, Chicago, Illinois, USAGianluca Iacobellis - Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Miami Miller School of Medicine, Miami, Florida, USA
- Resource Type
- Journal article
- Publication Details
- Obesity (Silver Spring, Md.), Vol.23(6), pp.1267-1278
- Publisher
- United States
- DOI
- 10.1002/oby.21059
- PMID
- 25959145
- PMCID
- PMC5003780
- ISSN
- 1930-7381
- eISSN
- 1930-739X
- Grant note
- R01 DK077148 / NIDDK NIH HHS R01 DK065055 / NIDDK NIH HHS
- Language
- English
- Date published
- 06/2015
- Academic Unit
- Surgery; Cardiothoracic Surgery
- Record Identifier
- 9984051800202771
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