Epidemiologic Study of Transfusion-Related Alpha-Gal Syndrome

Richard M. Kaufman; Anne G. Hoen; Jenna Khan; C. Michael Knudson; Ryan A. Metcalf; Andres E. Mindiola Romero; Allison Mo; Richard Schäfer; Minoko Takanashi; Nancy M. Dunbar; Sajjad Afraz; Elizabeth S. Allen; Jennifer Andrews; Konstanze Aurich; John Casey; Claudia S. Cohn; Jensyn K. Cone Sullivan; Clara C. Cousins; Elizabeth P. Crowe; Valeria De Giorgi; Meghan Delaney; Regina M. DelBaugh; Colleen W. Gilstad; Alexander Gofton; Jeanne E. Hendrickson; Kate Hill; Keenan O. Hogan; Catherine Humbrecht; Kazuhiko Ikeda; Cyril Jacquot; Ayda Javanbakht; Justin E Juskewitch; Wen Lu; Monique M. Menzies Wojtowicz; Maureen J. Miller; Georgia Mills; Anna C. Nelson; Monica B. Pagano; Marie C. Pauly; Jessica L. Poisson; Jay S. Raval; Nabiha H. Saifee; Nikitha Samy; Tomohiko Sato; Yoshinori Takeda; Suzanne R. Thibodeaux; Pierre Tiberghien; Sheryl van Nunen; Mrigender S. Virk; Kamille West-Mitchell; Erica M. Wood; Jun Yamanouchi; Satoshi Yoshihara; X. Long Zheng; Alyssa Ziman; UPTICK Study Group; for the Biomedical Excellence for Safer Transfusion (BEST) Collaborative

doi:10.1001/jamainternmed.2026.3983

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Epidemiologic Study of Transfusion-Related Alpha-Gal Syndrome

Journal article

Peer reviewed

Epidemiologic Study of Transfusion-Related Alpha-Gal Syndrome

Richard M. Kaufman, Anne G. Hoen, Jenna Khan, C. Michael Knudson, Ryan A. Metcalf, Andres E. Mindiola Romero, Allison Mo, Richard Schäfer, Minoko Takanashi, Nancy M. Dunbar, …

JAMA internal medicine

08/24/2026

DOI: 10.1001/jamainternmed.2026.3983

PMID: 42636004

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Abstract

This cohort study investigates the association of alpha-gal syndrome prevalence among patients with blood type O blood and rates of allergic transfusion reaction.

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Details

Title: Subtitle: Epidemiologic Study of Transfusion-Related Alpha-Gal Syndrome
Creators: Richard M. Kaufman - Dartmouth–Hitchcock Medical Center
Anne G. Hoen - Dartmouth College
Jenna Khan - University of Virginia Health System
C. Michael Knudson - University of Iowa
Ryan A. Metcalf - University of Utah
Andres E. Mindiola Romero - University of New Mexico
Allison Mo - Monash University
Richard Schäfer - University Medical Center Freiburg
Minoko Takanashi - Japanese Red Cross College of Nursing
Nancy M. Dunbar - Dartmouth–Hitchcock Medical Center
Sajjad Afraz - Stanford University
Elizabeth S. Allen - University of California San Diego
Jennifer Andrews - Vanderbilt University Medical Center
Konstanze Aurich - Universitätsmedizin Greifswald
John Casey - Australian Red Cross Lifeblood
Claudia S. Cohn - University of Minnesota System
Jensyn K. Cone Sullivan - University of Michigan
Clara C. Cousins - University of California, Los Angeles
Elizabeth P. Crowe - Johns Hopkins Medicine
Valeria De Giorgi - National Institutes of Health
Meghan Delaney - Children's National
Regina M. DelBaugh - Virginia Commonwealth University
Colleen W. Gilstad - Georgetown University
Alexander Gofton - Commonwealth Scientific and Industrial Research Organisation
Jeanne E. Hendrickson - Emory Healthcare
Kate Hill - Princess Alexandra Hospital
Keenan O. Hogan - University of Kansas Medical Center
Catherine Humbrecht - Établissement Français du Sang
Kazuhiko Ikeda - Fukushima Medical University
Cyril Jacquot - Children's National
Ayda Javanbakht - The University of Texas Southwestern Medical Center
Justin E Juskewitch - Mayo Clinic
Wen Lu - Mayo Clinic
Monique M. Menzies Wojtowicz - Macquarie University
Maureen J. Miller - National Institutes of Health
Georgia Mills - Macquarie University
Anna C. Nelson - Gosford Hospital
Monica B. Pagano - University of Washington
Marie C. Pauly - University Medical Center Freiburg
Jessica L. Poisson - Duke University
Jay S. Raval - University of Vermont
Nabiha H. Saifee - Seattle Children's Hospital
Nikitha Samy - The University of Texas Southwestern Medical Center
Tomohiko Sato - The Jikei University Hospital
Yoshinori Takeda - Georgetown University
Suzanne R. Thibodeaux - Washington University in St. Louis
Pierre Tiberghien - Université Marie et Louis Pasteur
Sheryl van Nunen - Macquarie University
Mrigender S. Virk - Stanford University
Kamille West-Mitchell - National Institutes of Health
Erica M. Wood - Monash University
Jun Yamanouchi - Ehime University
Satoshi Yoshihara - Hyogo University
X. Long Zheng - University of Kansas Medical Center
Alyssa Ziman - University of California, Los Angeles
UPTICK Study Group; for the Biomedical Excellence for Safer Transfusion (BEST) Collaborative
Resource Type: Journal article
Publication Details: JAMA internal medicine
DOI: 10.1001/jamainternmed.2026.3983
PMID: 42636004
ISSN: 2168-6106
eISSN: 2168-6114
Publisher: American Medical Association
Alternative title: Epidemiologic Study of Transfusion-Related Alpha-Gal Syndrome
Language: English
Electronic publication date: 08/24/2026
Academic Unit: Pathology
Record Identifier: 9985220839302771

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