Epidemiologic survey of infantile cancer in Iran based on the data of the largest pediatric cancer referral center (Ali- Asghar Children Hospital), 1996-2005

Gholamreza Bahoush-Mehdiabadi; Roshanak Habibi; Ahmad Shariftabrizi; Parvaneh Vossough

doi:10.7314/APJCP.2014.15.3.1211

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Epidemiologic survey of infantile cancer in Iran based on the data of the largest pediatric cancer referral center (Ali- Asghar Children Hospital), 1996-2005

Journal article

Open access

Peer reviewed

Epidemiologic survey of infantile cancer in Iran based on the data of the largest pediatric cancer referral center (Ali- Asghar Children Hospital), 1996-2005

Gholamreza Bahoush-Mehdiabadi, Roshanak Habibi, Ahmad Shariftabrizi and Parvaneh Vossough

Asian Pacific journal of cancer prevention : APJCP, Vol.15(3), pp.1211-1217

2014

DOI: 10.7314/APJCP.2014.15.3.1211

PMID: 24606443

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Abstract

Cancer in infants younger than one year of age represents a unique problem with distinct epidemiological, clinical and genetic characteristics compared with older age groups. No report is yet available from Iran regarding epidemiological and survival rate of cancers diagnosed in this age group. The population under study comprised of patients which were diagnosed and admitted to Ali-Asghar hospital between years 1996-2005. In total, 287 infants were included in the retrospective descriptive survey. Patient files were evaluated for age of patient at the time of diagnosis, sex, geographical residence, consanguinity of parents, histological diagnosis, site of cancer involvement, type of therapy, date of last follow-up and cause of death (if applicable). The average age at the time of diagnosis was 7.2 months old. The most frequent malignancy was retinoblastoma (44%), followed by leukemia (19%) and neuroblastoma (10%), with five-year overall survival rates of 77.7%, 41% and 90%, respectively Parents of 40 infants (13.9%) had consanguinity relationships. Although we cannot make any conclusions regarding the incidence of infant cancer subtypes based on this study, survival rates for major types were similar to the developed countries, which signifies strict adherence to standards of care in Ali-Asghar hospital, the main infant cancer care centre in Iran. A Childhood Cancer Registry with high-resolution data collection and also advanced genetic testing is advocated for in-depth analysis of variation in incidence and survival.

Central Nervous System Neoplasms - epidemiology

Central Nervous System Neoplasms - mortality

Consanguinity

Female

Hospitals, Pediatric

Humans

Infant

Infant, Newborn

Iran - epidemiology

Leukemia - epidemiology

Leukemia - mortality

Male

Neoplasms - epidemiology

Neoplasms - mortality

Neoplasms, Germ Cell and Embryonal - epidemiology

Neoplasms, Germ Cell and Embryonal - mortality

Neuroblastoma - epidemiology

Neuroblastoma - mortality

Retinoblastoma - epidemiology

Retinoblastoma - mortality

Retrospective Studies

Sarcoma - epidemiology

Sarcoma - mortality

Wilms Tumor - epidemiology

Wilms Tumor - mortality

Details

Title: Subtitle: Epidemiologic survey of infantile cancer in Iran based on the data of the largest pediatric cancer referral center (Ali- Asghar Children Hospital), 1996-2005
Creators: Gholamreza Bahoush-Mehdiabadi - Iran University of Medical Sciences
Roshanak Habibi
Ahmad Shariftabrizi
Parvaneh Vossough
Resource Type: Journal article
Publication Details: Asian Pacific journal of cancer prevention : APJCP, Vol.15(3), pp.1211-1217
DOI: 10.7314/APJCP.2014.15.3.1211
PMID: 24606443
NLM abbreviation: Asian Pac J Cancer Prev
ISSN: 1513-7368
eISSN: 2476-762X
Language: English
Date published: 2014
Academic Unit: Radiology
Record Identifier: 9984318791502771

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