Journal article
Epidemiological, Clinical, and Neuropathological Study of Apolipoprotein E Genotype in Alzheimer's Disease
Annals of the New York Academy of Sciences, Vol.802(1), pp.1-5
12/1996
DOI: 10.1111/j.1749-6632.1996.tb32592.x
PMID: 8993478
Abstract
Our studies of the APOE genotype in AD confirm a strong association of the ε4 allele with development of AD and a decreased risk associated with ε2. From a clinical/neuropathological perspective, the major effects of APOE ε4 are to lower the age of onset and to increase the amount of Aβ deposit in the brain. Neither rate of progression nor number of neurofibrillary tangles were affected. We also carried out a longitudinal population-based assessment of the APOE genotype to determine the risk for developing cognitive impairment of someone in the general population based on APOE genotype. APOE ε4 carried about 1.4-fold increased risk, and APOE ε2 about 1.7-fold decreased risk. Thus, inheritance of APOE ε4 is a major biological risk factor for AD, but it has limited utility as a prognostic indicator for development of dementia in an individual.
Details
- Title: Subtitle
- Epidemiological, Clinical, and Neuropathological Study of Apolipoprotein E Genotype in Alzheimer's Disease
- Creators
- BRADLEY T. Hyman - Massachusetts General HospitalTERESA GOMEZ-ISLA - Massachusetts General HospitalG. WILLIAM Rebeck - Massachusetts General HospitalMEGAN Briggs - Massachusetts General HospitalHAEYONG Chung - Massachusetts General HospitalHOWARD L. West - Massachusetts General HospitalSTEVEN Greenberg - Massachusetts General HospitalSTINA Mui - Massachusetts General HospitalSUSAN Nichols - University of IowaROBERT Wallace - University of IowaJOHN H. Growdon - Massachusetts General Hospital
- Resource Type
- Journal article
- Publication Details
- Annals of the New York Academy of Sciences, Vol.802(1), pp.1-5
- DOI
- 10.1111/j.1749-6632.1996.tb32592.x
- PMID
- 8993478
- NLM abbreviation
- Ann N Y Acad Sci
- ISSN
- 0077-8923
- eISSN
- 1749-6632
- Publisher
- Blackwell Publishing Ltd
- Number of pages
- 5
- Language
- English
- Date published
- 12/1996
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984364414802771
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