Journal article
Epidemiological and Experimental Evidence for Sex-Dependent Differences in the Outcome of Leishmania infantum Infection
The American journal of tropical medicine and hygiene, Vol.98(1), pp.142-145
01/2018
DOI: 10.4269/ajtmh.17-0563
PMCID: PMC5928733
PMID: 29165220
Abstract
causes visceral leishmaniasis (VL) in Brazil. We previously observed that VL is more common in males than females living in endemic neighborhoods, despite similar exposure. Using a larger sample, we document that VL is more common in males than females, but only after puberty. BALB/c and C57BL/6 mouse models confirmed that there is a biological basis for male susceptibility to symptomatic VL, showing higher parasite burdens in males than females. Female C57BL/6 mice generated more antigen-induced cytokines associated with curative responses (interferon-γ, interleukin [IL]-1β). Males expressed higher levels of IL-10 and tumor necrosis factor, which are linked to exacerbated disease. Different parasite lines entered or survived at a higher rate in macrophages of male- than female-origin. These results suggest that males are inherently more susceptible to
than females and that mice are a valid model to study this sex-dependent difference.
Details
- Title: Subtitle
- Epidemiological and Experimental Evidence for Sex-Dependent Differences in the Outcome of Leishmania infantum Infection
- Creators
- Nilda E Rodríguez - Department of Biology, University of Northern Iowa, Cedar Falls, IowaIraci D Lima - Fundação Nacional de Saúde, Secretaria de Saúde do Estado do Rio Grande do Norte, Natal, BrazilUpasna Gaur Dixit - Department of Internal Medicine, University of Iowa, Iowa City, IowaElizabeth A Turcotte - Department of Biology, University of Northern Iowa, Cedar Falls, IowaRyan D Lockard - Department of Biology, University of Northern Iowa, Cedar Falls, IowaHemali Batra-Sharma - Carver College of Medicine, University of Iowa, Iowa City, IowaEliana L Nascimento - Health Science Post-Graduate Program, Health Science Center, Federal University of Rio Grande do Norte, Natal, BrazilSelma M B Jeronimo - Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, BrazilMary E Wilson - Department of Internal Medicine, University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- The American journal of tropical medicine and hygiene, Vol.98(1), pp.142-145
- Publisher
- United States
- DOI
- 10.4269/ajtmh.17-0563
- PMID
- 29165220
- PMCID
- PMC5928733
- ISSN
- 0002-9637
- eISSN
- 1476-1645
- Grant note
- R01 AI045540 / NIAID NIH HHS I01 BX001983 / BLRD VA
- Language
- English
- Date published
- 01/2018
- Academic Unit
- Microbiology and Immunology; International Programs; Epidemiology; Internal Medicine
- Record Identifier
- 9984001141402771
Metrics
24 Record Views