Epidemiological risk factors for isolation of ceftriaxone-resistant versus -susceptible citrobacter freundii in hospitalized patients

Peter W Kim; Anthony D Harris; Mary-Claire Roghmann; J Glenn Morris Jr; Arjun Strinivasan; Eli N Perencevich

doi:10.1128/AAC.47.9.2882-2887.2003

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Epidemiological risk factors for isolation of ceftriaxone-resistant versus -susceptible citrobacter freundii in hospitalized patients

Journal article

Open access

Peer reviewed

Epidemiological risk factors for isolation of ceftriaxone-resistant versus -susceptible citrobacter freundii in hospitalized patients

Peter W Kim, Anthony D Harris, Mary-Claire Roghmann, J Glenn Morris Jr, Arjun Strinivasan and Eli N Perencevich

Antimicrobial agents and chemotherapy, Vol.47(9), pp.2882-2887

09/2003

DOI: 10.1128/AAC.47.9.2882-2887.2003

PMCID: PMC182594

PMID: 12936989

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Abstract

Antimicrobial resistance is an emerging problem among nosocomial bacteria. Risk factors for the recovery of ceftriaxone-resistant (CRCF) or -susceptible (CSCF) Citrobacter freundii in clinical cultures from hospitalized patients were determined by using a case-case-control study design. CRCF was isolated from 43 patients (case group 1) and CSCF was isolated from 87 patients (case group 2) over a 3-year period. Risk factors for CRCF were exposure to imipenem (odds ratio [OR], 7.5; 95% confidence interval [CI], 1.2 to 45.4), broad-spectrum cephalosporins (OR, 6.9; 95% CI, 1.8 to 26.7), vancomycin (OR, 3.0; 95% CI, 1.2 to 7.4), or piperacillin-tazobactam (OR, 2.6; 95% CI, 1.1 to 6.2), as well as hospital length of stay >or=1 week (OR, 3.6; 95% CI, 1.3 to 10.2) and intensive care unit (ICU) stay (OR, 2.6; 95% CI, 1.1 to 6.2). Risk factors for CSCF were peripheral vascular disease (OR, 23.2; 95% CI, 4.3 to 124.6), AIDS (OR, 9.5; 95% CI, 1.6 to 55.5), cerebrovascular disease (OR, 4.2; 95% CI, 1.6 to 10.8), and ICU stay (OR, 3.1; 95% CI, 1.8 to 5.4).

Critical Care

Length of Stay

Cephalosporin Resistance

Enterobacteriaceae Infections - microbiology

Humans

Middle Aged

Risk Factors

Ceftriaxone - pharmacology

Male

Case-Control Studies

Enterobacteriaceae Infections - complications

Enterobacteriaceae Infections - epidemiology

Citrobacter freundii - drug effects

Cerebrovascular Disorders - complications

Cross Infection - microbiology

Female

Cephalosporins - pharmacology

Cross Infection - epidemiology

Details

Title: Subtitle: Epidemiological risk factors for isolation of ceftriaxone-resistant versus -susceptible citrobacter freundii in hospitalized patients
Creators: Peter W Kim - Department of Epidemiology and Preventive Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. pkim@medicine.umaryland.edu
Anthony D Harris
Mary-Claire Roghmann
J Glenn Morris Jr
Arjun Strinivasan
Eli N Perencevich
Resource Type: Journal article
Publication Details: Antimicrobial agents and chemotherapy, Vol.47(9), pp.2882-2887
DOI: 10.1128/AAC.47.9.2882-2887.2003
PMID: 12936989
PMCID: PMC182594
NLM abbreviation: Antimicrob Agents Chemother
ISSN: 0066-4804
eISSN: 1098-6596
Publisher: United States
Grant note: K23 AI001752 / NIAID NIH HHS K23 AI01752-01A1 / NIAID NIH HHS
Language: English
Date published: 09/2003
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983779495102771

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