Journal article
Epidemiology and outcomes of candidemia in 3648 patients: data from the Prospective Antifungal Therapy (PATH Alliance®) registry, 2004–2008
Diagnostic microbiology and infectious disease, Vol.74(4), pp.323-331
12/2012
DOI: 10.1016/j.diagmicrobio.2012.10.003
PMID: 23102556
Abstract
This analysis describes the epidemiology and outcomes of candidemia in patients enrolled in the Prospective Antifungal Therapy Alliance (PATH Alliance®) registry from 2004 to 2008. Overall, 4067 Candida isolates were identified from 3648 patients. The most common Candida spp. were C. albicans (42.1%), C. glabrata (26.7%), C. parapsilosis (15.9%), C. tropicalis (8.7%), and C. krusei (3.4%). The proportion of candidemia caused by non-albicans Candida spp. (57.9%) was higher than that caused by C. albicans (42.1%). Infections with C. albicans were most common in neonatal intensive care unit (54.8%). In total, 3342 patients received antifungal therapy; fluconazole (66.0%) and echinocandins (50.5%) were most frequently administered. The 90-day survival rate for all patients was 61.3%. Among the most common Candida spp., the highest 90-day survival rate was observed for C. parapsilosis (70.0%) and the lowest for C. krusei (53.6%). In conclusion, this study expands the current knowledge of the epidemiology and outcomes of candidemia.
Details
- Title: Subtitle
- Epidemiology and outcomes of candidemia in 3648 patients: data from the Prospective Antifungal Therapy (PATH Alliance®) registry, 2004–2008
- Creators
- Michael Pfaller - JMI Laboratories, North Liberty, IA 52317, USADionissios Neofytos - Johns Hopkins Hospital, Baltimore, MD 21287, USADaniel Diekema - University of Iowa, Iowa City, IA 52242, USANkechi Azie - Astellas Scientific and Medical Affairs, Northbrook, IL 60062, USAHerwig-Ulf Meier-Kriesche - Astellas Scientific and Medical Affairs, Northbrook, IL 60062, USAShun-Ping Quan - Astellas Scientific and Medical Affairs, Northbrook, IL 60062, USADavid Horn - David Horn LLC, Doylestown, PA 18902, USA
- Resource Type
- Journal article
- Publication Details
- Diagnostic microbiology and infectious disease, Vol.74(4), pp.323-331
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.diagmicrobio.2012.10.003
- PMID
- 23102556
- ISSN
- 0732-8893
- eISSN
- 1879-0070
- Grant note
- name: Astellas
- Language
- English
- Date published
- 12/2012
- Academic Unit
- Infectious Diseases; Epidemiology; Pathology; Internal Medicine
- Record Identifier
- 9983986371102771
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