Journal article
Epidemiology of Bacteremia in Previously Healthy Febrile Infants: A Follow-up Study
Hospital pediatrics, Vol.5(6), pp.293-300
06/2015
DOI: 10.1542/hpeds.2014-0121
PMID: 26034160
Abstract
Describe the etiology of bacteremia among a geographically diverse sample of previously well infants with fever admitted for general pediatric care and to characterize demographic and clinical characteristics of infants with bacteremia according to bacterial etiology. We hypothesized that the epidemiology of bacteremia in febrile infants from a geographically diverse cohort would show similar results to smaller or single-center cohorts previously reported.
This was a retrospective review of positive, pathogenic blood cultures in previously healthy, febrile infants≤90 days old admitted to a general unit. In total, there were 17 participating sites from diverse geographic regions of the United States. Cultures were included if the results were positive for bacteria, obtained from an infant 90 days old or younger with a temperature≥38.0°C, analyzed using an automated detection system, and treated as pathogenic.
Escherichia coli was the most prevalent species, followed by group B Streptococcus, Streptococcus viridans, and Staphylococcus aureus. Among the most prevalent bacteria, there was no association between gender and species (Ps>.05). Age at presentation was associated only with Streptococcus pneumoniae. There were no cases of Listeria monocytogenes.
Our study confirms the data from smaller or single-center studies and suggests that the management of febrile well-appearing infants should change to reflect the current epidemiology of bacteremia. Further research is needed into the role of lumbar puncture, as well as the role of Listeria and Enterococcus species in infantile bacteremia.
Details
- Title: Subtitle
- Epidemiology of Bacteremia in Previously Healthy Febrile Infants: A Follow-up Study
- Creators
- Matthew Mischler - University of Illinois College of Medicine at Peoria, Peoria, Illinois mmisch1@uic.eduMichael S Ryan - Virginia Commonwealth University School of Medicine, Richmond, VirginiaJoAnna K Leyenaar - Tufts Medical Center, Boston, MassachusettsAllison Markowsky - The George Washington University School of Medicine, Washington, District of ColumbiaMidori Seppa - Stanford University, Palo Alto, CaliforniaKelly Wood - University of Iowa Children's Hospital, Iowa City, IowaJinma Ren - University of Illinois College of Medicine at Peoria, Peoria, IllinoisCarl Asche - University of Illinois College of Medicine at Peoria, College of Pharmacy, University of Illinois at Chicago, Chicago, IllinoisFrancis Gigliotti - University of Rochester Medical Center, Rochester, New YorkEric Biondi - University of Rochester Medical Center, Rochester, New York
- Resource Type
- Journal article
- Publication Details
- Hospital pediatrics, Vol.5(6), pp.293-300
- DOI
- 10.1542/hpeds.2014-0121
- PMID
- 26034160
- ISSN
- 2154-1663
- eISSN
- 2154-1671
- Language
- English
- Date published
- 06/2015
- Academic Unit
- Stead Family Department of Pediatrics; Hospital Medicine
- Record Identifier
- 9984093496502771
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