Journal article
Epidemiology of bloodstream infections in patients receiving long-term total parenteral nutrition
Journal of clinical gastroenterology, Vol.41(1), pp.19-28
01/2007
DOI: 10.1097/01.mcg.0000212606.13348.f7
PMID: 17198060
Abstract
To describe the epidemiology and microbiologic characteristics of bloodstream infections (BSIs) in patients receiving long-term total parenteral nutrition (TPN). Home TPN therapy has been reported as a risk factor for BSI. However, little knowledge exists regarding the epidemiology of BSIs in this patient group. A descriptive, observational epidemiologic study of patients receiving long-term TPN from January 1981 to July 2005 was performed. Variables analyzed include age, gender, time of follow-up, number of BSIs, microbiologic characteristics, underlying disease necessitating long-term TPN, catheter type, complications related to TPN, and clinical outcome. Forty-seven patients receiving long-term TPN were evaluated. The most frequent indication for long-term TPN was ischemic bowel disease (25.5%). The mean duration of follow-up was 4.5 years. Thirty-eight patients (80.9%) developed 248 BSIs while receiving TPN. More than 1 BSI episode occurred in 78.9% of these patients, and 23.8% of BSI episodes were polymicrobial. The most prevalent pathogen was coagulase negative staphylococci (33.5%). The most frequent complication among patients with BSI was central venous thrombosis (44.7%). Five patients were intravenous drug users. There were 11 deaths among the patients on long-term TPN, 4 of these were related to infection and 4 were related to intravenous drug use. The incidence of BSI is high, and a significant proportion of BSIs in long-term TPN patients are polymicrobial and due to multidrug-resistant bacteria and fungi. Careful management of the infusion line is required and interventions are needed to reduce the risk of catheter-related infections in this population.
Details
- Title: Subtitle
- Epidemiology of bloodstream infections in patients receiving long-term total parenteral nutrition
- Creators
- Alexandre R Marra - Division of Infectious Diseases, Universidade Federal de São Paulo (UNIFESP-EPM)/Hospital São Paulo, BrazilMarianne OpillaMichael B EdmondDonald F Kirby
- Resource Type
- Journal article
- Publication Details
- Journal of clinical gastroenterology, Vol.41(1), pp.19-28
- Publisher
- United States
- DOI
- 10.1097/01.mcg.0000212606.13348.f7
- PMID
- 17198060
- ISSN
- 0192-0790
- eISSN
- 1539-2031
- Language
- English
- Date published
- 01/2007
- Academic Unit
- Infectious Diseases; Internal Medicine
- Record Identifier
- 9983905640502771
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