Epidemiology of congenital cytomegalovirus infection: maternal risk factors and molecular analysis of cytomegalovirus strains

J R Murph; I E Souza; J D Dawson; Patricia Benson; S J Petheram; D Pfab; A Gregg; M E O'Neill; B Zimmerman; James F Bale Jr

doi:10.1093/oxfordjournals.aje.a009384

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Epidemiology of congenital cytomegalovirus infection: maternal risk factors and molecular analysis of cytomegalovirus strains

Journal article

Open access

Peer reviewed

Epidemiology of congenital cytomegalovirus infection: maternal risk factors and molecular analysis of cytomegalovirus strains

J R Murph, I E Souza, J D Dawson, Patricia Benson, S J Petheram, D Pfab, A Gregg, M E O'Neill, B Zimmerman and James F Bale Jr

American journal of epidemiology, Vol.147(10), pp.940-947

05/15/1998

DOI: 10.1093/oxfordjournals.aje.a009384

PMID: 9596472

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Abstract

To determine factors that influence the occurrence of congenital cytomegalovirus (CMV) infection, the authors surveyed prospectively 8,254 infants born in eastern Iowa between October 1989 and June 1994. The authors conducted a case-control study to identify maternal risk factors, matching each CMV-infected infant with three uninfected infants according to hospital and date of birth. CMV strains were compared by using the polymerase chain reaction (PCR) to identify common sources of infection. Of the 7,229 infants cultured successfully for CMV, 35 (0.48%) were congenitally infected. Mothers of CMV-infected infants were more likely to be single (odds ratio (OR) = 3.05, p = 0.016), to work in sales (OR = 4.93, p = 0.008), or to be students (OR = 5.01, p = 0.017). Conversely, women who worked in health-care professions were less likely to have a congenitally infected infant (OR = 0.14, p = 0.049). PCR analysis indicated 27 distinct strains of CMV, but two groups of infants (two infants per group) excreted strains with indistinguishable molecular patterns. One of these pairs of infants had older siblings who attended the same child-care center during their mothers' pregnancies. The authors concluded that demographic and occupational factors influenced the risk of giving birth to an infant with congenital CMV infection. Many distinct CMV strains were identified, suggesting that major point source outbreaks had not occurred. Nonetheless, point source acquisition of CMV from child-care environments did account for some cases of congenital CMV infection in eastern Iowa.

Polymerase Chain Reaction

Multivariate Analysis

Confidence Intervals

Age Distribution

Prospective Studies

Species Specificity

Cytomegalovirus Infections - epidemiology

Humans

Occupations

DNA, Viral - analysis

Mothers

Case-Control Studies

Incidence

Cytomegalovirus Infections - virology

Adult

Female

Iowa - epidemiology

Surveys and Questionnaires

Cytomegalovirus Infections - transmission

Women, Working

Cytomegalovirus Infections - congenital

Environmental Exposure - statistics & numerical data

Odds Ratio

Cytomegalovirus - classification

Infant, Newborn

Cytomegalovirus - genetics

Risk Factors

Genotype

Infectious Disease Transmission, Vertical

Regression Analysis

Polymorphism, Restriction Fragment Length

Population Surveillance

Details

Title: Subtitle: Epidemiology of congenital cytomegalovirus infection: maternal risk factors and molecular analysis of cytomegalovirus strains
Creators: J R Murph - Department of Pediatrics, The University of Iowa College of Medicine, Iowa City, USA
I E Souza
J D Dawson
Patricia Benson
S J Petheram
D Pfab
A Gregg
M E O'Neill
B Zimmerman
James F Bale Jr
Resource Type: Journal article
Publication Details: American journal of epidemiology, Vol.147(10), pp.940-947
DOI: 10.1093/oxfordjournals.aje.a009384
PMID: 9596472
NLM abbreviation: Am J Epidemiol
ISSN: 0002-9262
eISSN: 1476-6256
Publisher: United States
Grant note: HD22136 / NICHD NIH HHS
Language: English
Date published: 05/15/1998
Academic Unit: Public Health Administration; Stead Family Department of Pediatrics; Epidemiology; Biostatistics
Record Identifier: 9983997360902771

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