Journal article
Epidemiology of twinning in the National Birth Defects Prevention Study, 1997 to 2007
Birth defects research. A Clinical and molecular teratology, Vol.103(2), pp.85-99
02/2015
DOI: 10.1002/bdra.23325
PMCID: PMC4382674
PMID: 25359509
Abstract
Background
Our objective was to evaluate associations between twinning and maternal demographic factors and periconceptional exposures among infants with and without orofacial clefts.
Methods
We used data from the National Birth Defects Prevention Study; 228 twins and 8242 singletons without birth defects (controls), and 117 twins and 2859 singletons with orofacial clefts, born 1997 to 2007, were included in the analyses. Because of the occurrence of twinning due to the use of assisted reproductive technologies, logistic regression models were computed to estimate odds ratios and 95% confidence intervals for each exposure, stratified by fertility treatment use. To evaluate factors by zygosity, we used sex‐pairing data and a simulation approach to estimate the zygosity of like‐sex twin pairs for unassisted conceptions.
Results
Among control mothers who did not use fertility treatments, predictors of twinning included non‐Hispanic black maternal race (adjusted odds ratio, 1.6; 95% confidence interval, 1.0–2.4), and tobacco smoking (adjusted odds ratio, 1.6; 95% confidence interval, 1.1–2.4). Among control mothers who used fertility treatments, older maternal age, higher income, and state of residence were associated with twinning. Associations were generally stronger among mothers of dizygotic (estimated) twins than monozygotic (estimated) twins. Results for mothers of infants with isolated orofacial clefts were similar to those of controls.
Conclusion
We observed an increased twinning frequency with increasing maternal age, but factors such as maternal race/ethnicity and socioeconomic status may also contribute. Among women receiving fertility treatments, factors associated with twinning suggested a relation with treatment specifics (e.g., treatment type and number of embryos implanted) and availability of insurance coverage. Birth Defects Research (Part A) 103:85–99, 2015 © 2014 Wiley Periodicals, Inc.
Details
- Title: Subtitle
- Epidemiology of twinning in the National Birth Defects Prevention Study, 1997 to 2007
- Creators
- April L Dawson - Oak Ridge Institute for Science and EducationSarah C Tinker - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (CDC)Denise J Jamieson - National Center for Chronic Disease Prevention and Health Promotion, CDCCharlotte A Hobbs - College of Medicine, University of Arkansas for Medical SciencesSonja A Rasmussen - Office of Infectious DiseasesJennita Reefhuis - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (CDC)National Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- Birth defects research. A Clinical and molecular teratology, Vol.103(2), pp.85-99
- DOI
- 10.1002/bdra.23325
- PMID
- 25359509
- PMCID
- PMC4382674
- NLM abbreviation
- Birth Defects Res A Clin Mol Teratol
- ISSN
- 1542-0752
- eISSN
- 1542-0760
- Publisher
- Wiley
- Number of pages
- 15
- Grant note
- DOI: 10.13039/100000030, name: Centers for Disease Control and Prevention, award: DD09-001
- Language
- English
- Date published
- 02/2015
- Academic Unit
- Epidemiology; Biostatistics; Obstetrics and Gynecology; VPMA - Administration
- Record Identifier
- 9984214728702771
Metrics
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