Journal article
Epidermal Fatty Acid Binding Protein Mediates Depilatory-Induced Acute Skin Inflammation
Journal of investigative dermatology, Vol.142(7), pp.1824-1834.E7
07/2022
DOI: 10.1016/j.jid.2021.11.040
PMCID: PMC9639752
PMID: 34942197
Abstract
Depilatory creams are widely used to remove unwanted body hair, but people with “sensitive skin” are subject to depilatory-induced skin burn/inflammation. It remains unknown what makes their skin more sensitive than others. Herein, we demonstrate that epidermal fatty acid binding protein (E-FABP) expressed in the skin plays a critical role in promoting depilatory-induced acute skin inflammation in mouse models. While Nair, a common depilatory cream, removed hair by breaking down keratin disulfide bonds, it activated cytosolic phospholipase A2 (cPLA2), leading to activation of the arachidonic acid (AA)/E-FABP/PPARβ signaling pathway in keratinocytes. Specifically, PPARβ activation induced downstream targets (e.g. COX2) and chemokine (e.g. CXCL1) production, which systemically mobilized neutrophils and recruited them to localize in the skin for acute inflammatory responses. Importantly, E-FABP deletion by CRISPR-Cas9 reduced cPLA2/PPARβ activation in keratinocytes, and genetic deletion of E-FABP protected mice from Nair-induced neutrophil recruitment and skin inflammation. Our findings suggest E-FABP as a molecular sensor for “sensitive skin” by triggering depilatory-induced, lipid-mediated skin inflammatory responses.
Details
- Title: Subtitle
- Epidermal Fatty Acid Binding Protein Mediates Depilatory-Induced Acute Skin Inflammation
- Creators
- Di Yin - University of LouisvilleJiaqing Hao - University of LouisvilleRong Jin - University of LouisvilleYanmei Yi - University of LouisvilleSobha R Bodduluri - University of LouisvilleYuan Hua - University of LouisvilleAjay Anand - University of LouisvilleYibin Deng - University of Minnesota Medical SchoolBodduluri Haribabu - University of LouisvilleNejat K Egilmez - University of LouisvilleEdward R Sauter - Division of Cancer Prevention, NIH/NCI, Bethesda, MD, USABing Li - University of Louisville
- Resource Type
- Journal article
- Publication Details
- Journal of investigative dermatology, Vol.142(7), pp.1824-1834.E7
- DOI
- 10.1016/j.jid.2021.11.040
- PMID
- 34942197
- PMCID
- PMC9639752
- NLM abbreviation
- J Invest Dermatol
- ISSN
- 0022-202X
- eISSN
- 1523-1747
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: R01AI137324, R01CA180986; DOI: 10.13039/100000016, name: U.S. Department of Health and Human Services
- Language
- English
- Electronic publication date
- 12/20/2021
- Date published
- 07/2022
- Academic Unit
- Pathology
- Record Identifier
- 9984204061302771
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