Journal article
Epidermal Langerhans Cells in Cholesteatoma
Annals of otology, rhinology & laryngology, Vol.93(2), pp.150-156
03/1984
DOI: 10.1177/000348948409300210
PMID: 6712088
Abstract
The function of the epithelial component of a cholesteatoma has been the subject of intense research. The epithelium does not appear to have proteolytic enzyme activity, yet when it is present, increased amounts of bone resorption occur. Recent evidence suggests that epidermal Langerhans cells within epithelium have an immunologic alerting function. These cells were identified in normal tympanic membranes, canal skin, and cholesteatoma. The Langerhans cells in cholesteatoma displayed morphologic features similar to a contact hypersensitivity state. Langerhans cells within the epithelial matrix of the cholesteatoma may be responsible for generating and maintaining the chronic inflammatory reaction which induces bone resorption in this disease.
Details
- Title: Subtitle
- Epidermal Langerhans Cells in Cholesteatoma
- Creators
- Bruce J. Gantz
- Resource Type
- Journal article
- Publication Details
- Annals of otology, rhinology & laryngology, Vol.93(2), pp.150-156
- DOI
- 10.1177/000348948409300210
- PMID
- 6712088
- ISSN
- 0003-4894
- eISSN
- 1943-572X
- Language
- English
- Date published
- 03/1984
- Academic Unit
- Neurosurgery; Otolaryngology
- Record Identifier
- 9984303902002771
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