Journal article
Epidermal growth factor and phorbol esters reduce the levels of the cognate mRNA for the LH/CG receptor
Endocrinology (Philadelphia), Vol.128(5), pp.2651-2653
05/1991
DOI: 10.1210/endo-128-5-2651
PMID: 2019271
Abstract
The LH/CG receptor of MA-10 Leydig tumor cells can be down-regulated by LH/CG, mouse epidermal growth factor (mEGF), cAMP analogues and phorbol esters. In a recent publication we showed that the LH/CG-induced down regulation of the LH/CG receptor is primarily due to an increase in the rate of degradation of the receptor, and occurs with little or no change in the levels of LH/CG receptor mRNA. Although relatively unimportant for the LH/CG-induced down-regulation of the LH/CG receptor, we also found that LH/CG can in fact elicit a reduction in LH/CG receptor mRNA and that this reduction is mediated by cAMP. These findings raised the possibility that the ability of other compounds to down-regulate the LH/CG receptor may be accompanied by decreases in LH/CG receptor mRNA. In an attempt to answer this question, we examined the possibility that the mEGF- or phorbol ester-induced down regulation of the LH/CG receptor is due to changes in LH/CG receptor mRNA. The experiments presented herein show that this is indeed the case.
Details
- Title: Subtitle
- Epidermal growth factor and phorbol esters reduce the levels of the cognate mRNA for the LH/CG receptor
- Creators
- Haiyun WangDeborah L SegaloffMario Ascoli
- Resource Type
- Journal article
- Publication Details
- Endocrinology (Philadelphia), Vol.128(5), pp.2651-2653
- DOI
- 10.1210/endo-128-5-2651
- PMID
- 2019271
- ISSN
- 0013-7227
- eISSN
- 1945-7170
- Language
- English
- Date published
- 05/1991
- Academic Unit
- Molecular Physiology and Biophysics; Obstetrics and Gynecology; Neuroscience and Pharmacology
- Record Identifier
- 9984083865502771
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