Epigenetic signals associated with delirium replicated across four independent cohorts

Yoshitaka Nishizawa; Kaitlyn C Thompson; Takehiko Yamanashi; Nadia E Wahba; Taku Saito; Pedro S Marra; Takaaki Nagao; Tsuyoshi Nishiguchi; Kazuki Shibata; Kyosuke Yamanishi; Christopher G Hughes; Pratik Pandharipande; Hyunkeun Cho; Matthew A Howard; Hiroto Kawasaki; Hiroyuki Toda; Tetsufumi Kanazawa; Masaaki Iwata; Gen Shinozaki

doi:10.1038/s41398-024-02986-w

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Epigenetic signals associated with delirium replicated across four independent cohorts

Journal article

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Epigenetic signals associated with delirium replicated across four independent cohorts

Yoshitaka Nishizawa, Kaitlyn C Thompson, Takehiko Yamanashi, Nadia E Wahba, Taku Saito, Pedro S Marra, Takaaki Nagao, Tsuyoshi Nishiguchi, Kazuki Shibata, Kyosuke Yamanishi, …

Translational psychiatry, Vol.14(1), 275

07/04/2024

DOI: 10.1038/s41398-024-02986-w

PMCID: PMC11224347

PMID: 38965205

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Abstract

Delirium is risky and indicates poor outcomes for patients. Therefore, it is crucial to create an effective delirium detection method. However, the epigenetic pathophysiology of delirium remains largely unknown. We aimed to discover reliable and replicable epigenetic (DNA methylation: DNAm) markers that are associated with delirium including post-operative delirium (POD) in blood obtained from patients among four independent cohorts. Blood DNA from four independent cohorts (two inpatient cohorts and two surgery cohorts; 16 to 88 patients each) were analyzed using the Illumina EPIC array platform for genome-wide DNAm analysis. We examined DNAm differences in blood between patients with and without delirium including POD. When we compared top CpG sites previously identified from the initial inpatient cohort with three additional cohorts (one inpatient and two surgery cohorts), 11 of the top 13 CpG sites showed statistically significant differences in DNAm values between the delirium group and non-delirium group in the same directions as found in the initial cohort. This study demonstrated the potential value of epigenetic biomarkers as future diagnostic tools. Furthermore, our findings provide additional evidence of the potential role of epigenetics in the pathophysiology of delirium including POD.

Epigenetics

Pathophysiology

Delirium

DNA methylation

Details

Title: Subtitle: Epigenetic signals associated with delirium replicated across four independent cohorts
Creators: Yoshitaka Nishizawa - Stanford University
Kaitlyn C Thompson
Takehiko Yamanashi - Stanford University
Nadia E Wahba - Oregon Health & Science University
Taku Saito - National Defense Medical College
Pedro S Marra - University of Iowa
Takaaki Nagao - University of Iowa
Tsuyoshi Nishiguchi - Stanford University
Kazuki Shibata - Stanford University
Kyosuke Yamanishi - Stanford University
Christopher G Hughes - Vanderbilt University Medical Center
Pratik Pandharipande - Vanderbilt University Medical Center
Hyunkeun Cho - University of Iowa, Biostatistics
Matthew A Howard - University of Iowa
Hiroto Kawasaki - University of Iowa, Neurosurgery
Hiroyuki Toda - National Defense Medical College
Tetsufumi Kanazawa - Osaka University of Pharmaceutical Sciences
Masaaki Iwata - Tottori University
Gen Shinozaki - University of Iowa
Resource Type: Journal article
Publication Details: Translational psychiatry, Vol.14(1), 275
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-024-02986-w
PMID: 38965205
PMCID: PMC11224347
ISSN: 2158-3188
eISSN: 2158-3188
Language: English
Date published: 07/04/2024
Academic Unit: Neurology; Psychiatry; Iowa Neuroscience Institute; Biostatistics; Neurosurgery; Otolaryngology
Record Identifier: 9984652254802771

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