Journal article
Epigenetics in breast cancer: what's new?
Breast cancer research : BCR, Vol.13(6), pp.225-225
11/01/2011
DOI: 10.1186/bcr2925
PMCID: PMC3326545
PMID: 22078060
Abstract
Epigenetic changes are critical for development and progression of cancers, including breast cancer. Significant progress has been made in the basic understanding of how various epigenetic changes such as DNA methylation, histone modification, miRNA expression, and higher order chromatin structure affect gene expression. The present review will focus on methylation and demethylation of histones. While the acetylation of histones has been at the forefront of well-characterized post-translational modifications of histones, including the development of inhibitors targeting de-acetylating enzymes, the past few years have witnessed a dramatic increase in knowledge regarding the role of histone methylation/demethylation. This is an exciting and rapidly evolving area of research, with much promise for potential clinical intervention in several cancers including breast cancer. We also summarize efforts to identity DNA methylation signatures that could be prognostic and/or predictive markers in breast cancer, focusing on recent studies using genome-wide approaches. Finally, we briefly review the efforts made by both the National Institutes of Health Epigenome Project and The Cancer Genome Atlas, especially highlighting the study of breast cancer epigenetics, exciting technological advances, potential roadblocks, and future directions.
Details
- Title: Subtitle
- Epigenetics in breast cancer: what's new?
- Creators
- Yi Huang - UPMC Hillman Cancer CenterShweta Nayak - University of PittsburghRachel Jankowitz - University of PittsburghNancy E Davidson - UPMC Hillman Cancer CenterSteffi Oesterreich - UPMC Hillman Cancer Center
- Resource Type
- Journal article
- Publication Details
- Breast cancer research : BCR, Vol.13(6), pp.225-225
- Publisher
- BioMed Central
- DOI
- 10.1186/bcr2925
- PMID
- 22078060
- PMCID
- PMC3326545
- ISSN
- 1465-5411
- eISSN
- 1465-542X
- Language
- English
- Date published
- 11/01/2011
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984383278402771
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