Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging

Gen Shinozaki; Patricia R Braun; Benjamin W. Q Hing; Andrew Ratanatharathorn; Mason J Klisares; Gabrielle N Duncan; Sydney S Jellison; Jonathan T Heinzman; Yasunori Nagahama; Liesl Close; Sayeh Sabbagh; Brian J Dlouhy; Matthew A Howard; Hiroto Kawasaki; Hyunkeun R Cho

doi:10.3389/fnagi.2018.00311

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Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging

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Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging

Gen Shinozaki, Patricia R Braun, Benjamin W. Q Hing, Andrew Ratanatharathorn, Mason J Klisares, Gabrielle N Duncan, Sydney S Jellison, Jonathan T Heinzman, Yasunori Nagahama, Liesl Close, …

Frontiers in aging neuroscience, Vol.10, pp.311-311

10/23/2018

DOI: 10.3389/fnagi.2018.00311

PMID: 30405391

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Abstract

Background: Delirium in elderly patients is common and dangerous. Major risk factors include aging and exogenous insults, such as infection or surgery. In animal models, aging enhances pro-inflammatory cytokine release from microglia in response to exogenous insults. The epigenetic mechanism DNA methylation (DNAm) regulates gene expression and changes with age. Older individuals may have methylation changes that influence the increased cytokine upon insult, but the degree to which aging affects DNAm of cytokine genes is not fully understood. Methods: The relationship between DNAm and aging of pro-inflammatory cytokine genes (TNF-alpha, IL1-beta, IL-6) was investigated using methylation array data in two cohorts. Brain and blood samples were collected from a neurosurgery cohort (NSG) of 21 subjects who underwent brain resection. A second cohort, the Grady Trauma Project (GTP), included blood samples from 265 subjects. Results: In the NSG cohort, a significant negative correlation between age and DNAm in brain was found at a CpG in IL-6. With the GTP dataset, significant negative correlations between age and DNAm were seen at most of the CpGs in TNF-alpha. Also, TNF-Alpha expression increases with age. These GTP DNAm correlations were also nominally significant in NSG blood samples. In neuronal negative NSG brain tissue, a similar negative trend was observed. Conclusions: With aging, a decrease in DNAm of cytokines gene CpGs in glia and blood was seen. As this can affect their expression, additional research is needed to fully elucidate the role of DNAm in aging and how it may influence the pathogenesis of delirium.

Neuroscience

Aging

Epigenetics

cytokine

DNA methylation

tNF-alpha

delirium

Details

Title: Subtitle: Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging
Creators: Gen Shinozaki - ,
Patricia R Braun - ,
Benjamin W. Q Hing - ,
Andrew Ratanatharathorn - ,
Mason J Klisares - ,
Gabrielle N Duncan - ,
Sydney S Jellison - ,
Jonathan T Heinzman - ,
Yasunori Nagahama - ,
Liesl Close - ,
Sayeh Sabbagh - ,
Brian J Dlouhy - ,
Matthew A Howard - University of Iowa, Neurosurgery
Hiroto Kawasaki - ,
Hyunkeun R Cho - ,
Resource Type: Journal article
Publication Details: Frontiers in aging neuroscience, Vol.10, pp.311-311
DOI: 10.3389/fnagi.2018.00311
PMID: 30405391
NLM abbreviation: Front Aging Neurosci
ISSN: 1663-4365
eISSN: 1663-4365
Publisher: Frontiers Media S.A
Language: English
Date published: 10/23/2018
Academic Unit: Neurology; Molecular Physiology and Biophysics; Psychiatry; Iowa Neuroscience Institute; Biostatistics; Anesthesia; Neurosurgery; Otolaryngology
Record Identifier: 9983997315302771

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