Journal article
Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR
Nature communications, Vol.11(1), pp.5965-5965
11/24/2020
DOI: 10.1038/s41467-020-19615-x
PMCID: PMC7686485
PMID: 33235198
Abstract
Epigenetic differences may help to distinguish between PTSD cases and trauma-exposed controls. Here, we describe the results of the largest DNA methylation meta-analysis of PTSD to date. Ten cohorts, military and civilian, contribute blood-derived DNA methylation data from 1,896 PTSD cases and trauma-exposed controls. Four CpG sites within the aryl-hydrocarbon receptor repressor (AHRR) associate with PTSD after adjustment for multiple comparisons, with lower DNA methylation in PTSD cases relative to controls. Although AHRR methylation is known to associate with smoking, the AHRR association with PTSD is most pronounced in non-smokers, suggesting the result was independent of smoking status. Evaluation of metabolomics data reveals that AHRR methylation associated with kynurenine levels, which are lower among subjects with PTSD. This study supports epigenetic differences in those with PTSD and suggests a role for decreased kynurenine as a contributor to immune dysregulation in PTSD.
Details
- Title: Subtitle
- Epigenome-wide meta-analysis of PTSD across 10 military and civilian cohorts identifies methylation changes in AHRR
- Creators
- Alicia K Smith - Emory University, Department of Psychiatry & Behavioral Sciences, Atlanta, GA, USA. alicia.smith@emory.eduAndrew Ratanatharathorn - Columbia University, Department of Epidemiology, New York, NY, USAAdam X Maihofer - University of California San Diego, Department of Psychiatry, La Jolla, CA, USARobert K Naviaux - University of California, The Mitochondrial and Metabolic Disease Center, Departments of Medicine, Pediatrics, and Pathology, San Diego, CA, USAAllison E Aiello - University of North Carolina, Gillings School of Global Public Health, Department of Epidemiology, Chapel Hill, NC, USAAnanda B Amstadter - Virginia Commonwealth University, Department of Psychiatry, Richmond, VA, USAAllison E Ashley-Koch - Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USADewleen G Baker - Veterans Affairs Center of Excellence for Stress and Mental Health, San Diego, CA, USAJean C Beckham - Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, NC, USAMarco P Boks - University Medical Center Utrecht, Brain Center Rudolf Magnus, Utrecht, The NetherlandsEvelyn Bromet - State University of New York at Stony Brook, Epidemiology Research Group, Stony Brook, NY, USAMichelle Dennis - Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, NC, USASandro Galea - Boston University, School of Public Health, Boston, MA, USAMelanie E Garrett - Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USAElbert Geuze - Netherlands Ministry of Defence, Brain Research and Innovation Centre, Utrecht, The NetherlandsGuia Guffanti - Harvard Medical School, Boston, MA, USAMichael A Hauser - Duke University, Department of Medicine, Durham, NC, USASeyma Katrinli - Emory University, Department of Gynecology and Obstetrics, Atlanta, GA, USAVarun Kilaru - Emory University, Department of Gynecology and Obstetrics, Atlanta, GA, USARonald C Kessler - Harvard Medical School, Boston, MA, USANathan A Kimbrel - Duke University Medical Center, Department of Psychiatry and Behavioral Sciences, Durham, NC, USAKarestan C Koenen - Broad Institute of MIT and Harvard, Stanley Center for Psychiatric Research, Cambridge, MA, USAPei-Fen Kuan - State University of New York at Stony Brook, Department of Applied Mathematics and Statistics, Stony Brook, NY, USAKefeng Li - University of California, The Mitochondrial and Metabolic Disease Center, Department of Medicine, San Diego, CA, USAMark W Logue - Boston University School of Public Health, Department of Biostatistics, Boston, MA, USAAdriana Lori - Emory University, Department of Psychiatry & Behavioral Sciences, Atlanta, GA, USABenjamin J Luft - State University of New York at Stony Brook, Department of Medicine, Stony Brook, NY, USAMark W Miller - Boston University School of Medicine, Department of Psychiatry, Boston, MA, USAJane C Naviaux - University of California, The Mitochondrial and Metabolic Disease Center, Department of Neuroscience, San Diego, CA, USANicole R Nugent - Brown University, Psychiatry and Human Behavior, Department of Pediatric Research, Providence, RI, USAXuejun Qin - Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USAKerry J Ressler - Harvard Medical School, Boston, MA, USAVictoria B Risbrough - Veterans Affairs Center of Excellence for Stress and Mental Health, San Diego, CA, USABart P F Rutten - Maastricht University Medical Centre, School for Mental Health and Neuroscience, Department of Psychiatry and Neuropsychology, Maastricht, The NetherlandsMurray B Stein - University of California San Diego, Department of Family Medicine and Public Health, La Jolla, CA, USARobert J Ursano - Uniformed Services University School of Medicine, Center for the Study of Traumatic Stress, Bethesda, MD, USAEric Vermetten - Arq Psychotrauma Expert Group, Diemen, The NetherlandsChristiaan H Vinkers - Amsterdam UMC (location VUmc), Department of Anatomy and Neurosciences, Amsterdam, The NetherlandsLin Wang - University of California, The Mitochondrial and Metabolic Disease Center, Department of Medicine, San Diego, CA, USANagy A Youssef - Medical College of Georgia at Augusta University, Department of Psychiatry and Human Behavior and Office of Academic Affairs, Augusta, GA, USAMonica Uddin - University of South Florida, College of Public Health, Tampa, FL, USACaroline M Nievergelt - Veterans Affairs Center of Excellence for Stress and Mental Health, San Diego, CA, USAINTRuST Clinical ConsortiumVA Mid-Atlantic MIRECC WorkgroupPGC PTSD Epigenetics Workgroup
- Contributors
- Gen Shinozaki (Contributor) - University of Iowa, Psychiatry
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.11(1), pp.5965-5965
- DOI
- 10.1038/s41467-020-19615-x
- PMID
- 33235198
- PMCID
- PMC7686485
- NLM abbreviation
- Nat Commun
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Publisher
- England
- Grant note
- R01 DA022720 / NIDA NIH HHS R56 MH071537 / NIMH NIH HHS I01 BX002577 / BLRD VA R01 MH106595 / NIMH NIH HHS R01 MH071537 / NIMH NIH HHS R01 MH093500 / NIMH NIH HHS I01 BX002150 / BLRD VA U01 MH087981 / NIMH NIH HHS R01 MH096764 / NIMH NIH HHS IK2 CX000525 / CSRD VA U01 OH010416 / NIOSH CDC HHS R01 MH079806 / NIMH NIH HHS I01 CX000431 / CSRD VA RC1 MH088283 / NIMH NIH HHS R01 MH108826 / NIMH NIH HHS
- Language
- English
- Date published
- 11/24/2020
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute; Anesthesia; Neurosurgery
- Record Identifier
- 9984070589502771
Metrics
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