Journal article
Epinephrine Autoinjector Prescribing Trends: An Outpatient Population-Based Study in Olmsted County, Minnesota
The journal of allergy and clinical immunology in practice (Cambridge, MA), Vol.4(6), pp.1182-1186.e1
11/01/2016
DOI: 10.1016/j.jaip.2016.05.006
PMCID: PMC5107144
PMID: 27283053
Abstract
BACKGROUND: The prescribing pattern of epinephrine over time is an indicator of the secular trend of anaphylaxis. However, it is not well known in a population level in the United States.
OBJECTIVE: To evaluate the trend of prescriptions for epinephrine autoinjectors in Olmsted County, Minn, residents.
METHODS: Outpatient prescriptions for epinephrine were identified among residents of Olmsted County, Minn, between January 1, 2004, and December 31, 2010. We used the first prescription per patient per year, and the first prescription per patient during the study period to calculate incidence rates. Incidence rates per 100,000 person-years were calculated using patients prescribed epinephrine per year as the numerator and age-and sex-specific counts of the population of Olmsted County as the denominator. The relationships of age group, sex, and year of prescription with incidence rates were assessed by fitting Poisson regression models using the SAS procedure GENMOD.
RESULTS: The overall incidence rate of epinephrine autoinjector prescriptions during the study period was 757 per 100,000 person-years (95% confidence interval: 740-774). The prescription rates per patient per year increased over time, with an annual rate of increase of 8% (P < .001), but the rates per patient remained stable (P = .077). For each year, incidence rates overall were higher in women compared with men (P < .001). From ages 0 to 19, incidence rates were higher in boys compared with girls. At age 20 and above, incidence rates were higher in women compared with men.
CONCLUSIONS: The overall rate of epinephrine autoinjector prescriptions increased, but the rate of first-time prescriptions was stable from 2005 to 2010. In childhood, boys were more likely to receive a prescription than girls, but this reversed in later ages. (C) 2016 American Academy of Allergy, Asthma & Immunology
Details
- Title: Subtitle
- Epinephrine Autoinjector Prescribing Trends: An Outpatient Population-Based Study in Olmsted County, Minnesota
- Creators
- Sangil Lee - Mayo Clinic Health SystemErik P. Hess - Mayo Clinic in FloridaChristine Lohse - Mayo Clinic in FloridaDante Lucas S. Souza - Mayo ClinicRonna L. Campbell - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- The journal of allergy and clinical immunology in practice (Cambridge, MA), Vol.4(6), pp.1182-1186.e1
- DOI
- 10.1016/j.jaip.2016.05.006
- PMID
- 27283053
- PMCID
- PMC5107144
- NLM abbreviation
- J Allergy Clin Immunol Pract
- ISSN
- 2213-2198
- eISSN
- 2213-2201
- Publisher
- Elsevier
- Number of pages
- 6
- Grant note
- UL1 TR000135 / Clinical and Translational Science Award from National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH) R01AG034676 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R01AR030582 / NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin Diseases (NIAMS) R01AG034676 / National Institute on Aging of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Language
- English
- Date published
- 11/01/2016
- Academic Unit
- Emergency Medicine; Injury Prevention Research Center
- Record Identifier
- 9984297134602771
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