Journal article
Epinephrine increases mortality after brief asphyxial cardiac arrest in an in vivo rat model
Anesthesia and analgesia, Vol.102(2), pp.542-548
2006
DOI: 10.1213/01.ane.0000195231.81076.88
PMID: 16428558
Abstract
Epinephrine may be detrimental in cardiac arrest. In this laboratory study we sought to characterize the effect of epinephrine and concomitant calcium channel blockade on postresuscitation myocardial performance after brief asphyxial cardiac arrest. Anesthesized rats were disconnected from mechanical ventilation, resulting in cardiac arrest. Resuscitation was attempted after 1 min with mechanical ventilation, oxygen, chest compressions, and IV medication. In experimental series 1 and 2, animals were allocated to 10 or 30 microg/kg epinephrine or 0.9% saline. In series 3, animals received 30 microg/kg of epinephrine and were randomized to 0.1 mg/kg of verapamil or to 0.9% saline. In series 1 and 3, left ventricular function was assessed using transthoracic echocardiography. In series 2, left atrial pressure was measured. Epinephrine was associated with increased mortality (0/8 [0%] in controls, 4/12 [33.3%] in 10 microg/kg animals, and 16/22 [72.8%] in 30 microg/kg animals; P < 0.05), hypertension (P < 0.001), tachycardia (P = 0.004), early transient left atrial hypertension, and dose-related reduction in left ventricular end diastolic diameter (P < 0.05). Verapamil prevented mortality associated with large-dose epinephrine (0% versus 100%) and attenuated early diastolic dysfunction and postresuscitation hypertension (P = 0.001) without systolic dysfunction. Epinephrine appears to be harmful in the setting of brief cardiac arrest after asphyxia.
Details
- Title: Subtitle
- Epinephrine increases mortality after brief asphyxial cardiac arrest in an in vivo rat model
- Creators
- Conan L MCCAUL - The Lung Biology Program, The Research Institute, The Hospital for Sick Children, CanadaPatrick J MCNAMARA - The Lung Biology Program, The Research Institute, The Hospital for Sick Children, CanadaDoreen ENGELBERTS - The Lung Biology Program, The Research Institute, The Hospital for Sick Children, CanadaGregory J WILSON - Department of Pathology, The Hospital for Sick Children, CanadaAlex ROMASCHIN - Department of Pathology, The Hospital for Sick Children, CanadaAndrew N REDINGTON - Department of Cardiology, The Hospital for Sick Children, CanadaBrian P KAVANAGH - The Lung Biology Program, The Research Institute, The Hospital for Sick Children, Canada
- Resource Type
- Journal article
- Publication Details
- Anesthesia and analgesia, Vol.102(2), pp.542-548
- Publisher
- Lippincott
- DOI
- 10.1213/01.ane.0000195231.81076.88
- PMID
- 16428558
- ISSN
- 0003-2999
- eISSN
- 1526-7598
- Language
- English
- Date published
- 2006
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984093462402771
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