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Epinephrine induced cardiomyopathy in a child with anaphylaxis
Journal article   Open access   Peer reviewed

Epinephrine induced cardiomyopathy in a child with anaphylaxis

Madhuradhar Chegondi, Andre Raszynski and Balagangadhar R. Totapally
Signa vitae, Vol.11(1), pp.207-213
05/01/2016
DOI: 10.22514/SV111.052016.14
url
https://doi.org/10.22514/SV111.052016.14View
Published (Version of record) Open Access

Abstract

Transient cardiomyopathy is an uncommon occurrence in patients with anaphylaxis. Catecholamine induced direct toxicity is one of the proposed mechanisms. We report a case of cardiomyopathy in a child with anaphylaxis who was treated with multiple doses of epinephrine as well as a continuous infusion of epinephrine. A twenty one month old girl with egg allergy presented to our hospital with anaphylaxis, after multiple doses of epinephrine injections, developed cardiorespiratory dysfunction and required endotracheal intubation and mechanical ventilation. Work up showed depressed cardiac function, which improved with milrinone and furosemide infusions. Conclusion: Epinephrine is the treatment of choice for anaphylaxis however caution should be exercised when administering multiple doses of epinephrine. Myocardial function needs to be assessed in children with persistent hypotension after anaphylaxis and catecholamine-induced cardiomyopathy should be considered in children with anaphylaxis when severe myocardial dysfunction is present.
 Emergency Medicine Life Sciences & Biomedicine Science & Technology

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