Epithelial-Mesenchymal Transition Polarization in Ovarian Carcinomas From Patients With High Social Isolation

Susan K Lutgendorf; Frank Penedo; Michael J Goodheart; Laila Dahmoush; Jesusa M.G Arevalo; Premal H Thaker; George M Slavich; Anil K Sood; Steve W Cole

doi:10.1002/cncr.33060

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Epithelial-Mesenchymal Transition Polarization in Ovarian Carcinomas From Patients With High Social Isolation

Journal article

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Epithelial-Mesenchymal Transition Polarization in Ovarian Carcinomas From Patients With High Social Isolation

Susan K Lutgendorf, Frank Penedo, Michael J Goodheart, Laila Dahmoush, Jesusa M.G Arevalo, Premal H Thaker, George M Slavich, Anil K Sood and Steve W Cole

Cancer, Vol.126(19), pp.4407-4413

10/01/2020

DOI: 10.1002/cncr.33060

PMID: 32691853

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https://www.ncbi.nlm.nih.gov/pmc/articles/7719066View

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Abstract

● Social isolation has shown robust associations with clinical outcomes in the general population and in patients with cancer. Herein, the authors examined the relationship between social isolation and the molecular characteristics of ovarian tumors. ● The authors investigated the epithelial-mesenchymal transition (EMT), a process whereby tumor cells lose epithelial characteristics and become more embryonic (mesenchymal), thereby enhancing invasiveness. ● Primary analyses demonstrated lower expression of genes previously associated with epithelial differentiation and increased activity of specific EMT-related transcription factors in individuals with high social isolation, indicating increased EMT polarization in these patients. These findings extend the understanding of how socioenvironmental factors may modulate tumor growth.

Ovarian Cancer

social isolation

epithelial-mesenchymal transition

transcriptome

biobehavioral

treatment resistance

Details

Title: Subtitle: Epithelial-Mesenchymal Transition Polarization in Ovarian Carcinomas From Patients With High Social Isolation
Creators: Susan K Lutgendorf - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa
Frank Penedo - Department of Psychology, University of Miami, Miami, Florida
Michael J Goodheart - Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa
Laila Dahmoush - Department of Pathology, University of Iowa, Iowa City, Iowa
Jesusa M.G Arevalo - Division of Hematology/Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California
Premal H Thaker - Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, Missouri
George M Slavich - Cousins Center for Psychoneuroimmunology, University of California at Los Angeles, Los Angeles, California
Anil K Sood - Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas
Steve W Cole - Division of Hematology/Oncology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California
Resource Type: Journal article
Publication Details: Cancer, Vol.126(19), pp.4407-4413
DOI: 10.1002/cncr.33060
PMID: 32691853
NLM abbreviation: Cancer
ISSN: 0008-543X
eISSN: 1097-0142
Grant note: DOI: 10.13039/100000049, name: National Institute on Aging, award: AG043404, AG17265; DOI: 10.13039/100000054, name: National Cancer Institute, award: CA109298, CA140933, CA193249, CA209904, CA246540, P30CA086862
Language: English
Date published: 10/01/2020
Academic Unit: Psychological and Brain Sciences; Pathology; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
Record Identifier: 9984065882902771

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