Journal article
Epithelial-Mesenchymal Transition Protein Expression in Basal Cell Adenomas and Basal Cell Adenocarcinomas
Head & neck pathology (Totowa, N.J.), Vol.10(2), pp.176-181
06/2016
DOI: 10.1007/s12105-015-0657-6
PMCID: PMC4838958
PMID: 26442856
Abstract
Basal cell adenomas and basal cell adenocarcinomas show marked histomorphologic similarity and are separated microscopically primarily by the invasive characteristics of the adenocarcinomas. We wished to explore potential differences in the expression of epithelial-mesenchymal transition associated proteins in these two tumor types. A tissue microarray was constructed utilizing 29 basal cell adenomas and 16 basal cell adenocarcinomas. Immunohistochemical expression of E-cadherin, beta-catenin, Twist 1 and vimentin were investigated. Both tumors expressed all proteins in a relatively similar manner. Nuclear beta-catenin was essentially limited to the abluminal cell populations in both tumor types. E-cadherin was limited largely to luminal locations but was more prevalent in the adenocarcinomas as compared to the adenomas. Primarily abluminal expression for vimentin was seen, sometimes present in an apical dot-like pattern. Distinct populations of cellular expression of these four markers of epithelial mesenchymal transition were present but were similar in locations in both tumors with no patterns discerned to separate basal cell adenoma from basal cell adenocarcinoma. Given these findings, the mechanisms by which basal cell adenocarcinoma is able to invade while its counterpart, basal cell adenoma can not, may be more complex than in other tumor types.
Details
- Title: Subtitle
- Epithelial-Mesenchymal Transition Protein Expression in Basal Cell Adenomas and Basal Cell Adenocarcinomas
- Creators
- Brennan A Tesdahl - Department of Pathology, Carver College of Medicine, University of Iowa Hospitals and Clinics, 5238H RCP, 200 Hawkins Drive, Iowa City, IA, 52242, USAThomas C Wilson - Department of Pathology, Carver College of Medicine, University of Iowa Hospitals and Clinics, 5238H RCP, 200 Hawkins Drive, Iowa City, IA, 52242, USAHenry T Hoffman - Department Otolaryngology-Head and Neck Surgery, Carver College of Medicine, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52242, USARobert A Robinson - Department of Pathology, Carver College of Medicine, University of Iowa Hospitals and Clinics, 5238H RCP, 200 Hawkins Drive, Iowa City, IA, 52242, USA. robert-a-robinson@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Head & neck pathology (Totowa, N.J.), Vol.10(2), pp.176-181
- Publisher
- United States
- DOI
- 10.1007/s12105-015-0657-6
- PMID
- 26442856
- PMCID
- PMC4838958
- ISSN
- 1936-055X
- eISSN
- 1936-0568
- Language
- English
- Date published
- 06/2016
- Academic Unit
- Oral Pathology, Radiology and Medicine; Pathology; Radiation Oncology; Otolaryngology
- Record Identifier
- 9984006355402771
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