Journal article
Epithelial Sodium Channel Inhibition by Amiloride on Blood Pressure and Cardiovascular Disease Risk in Young Prehypertensives
The journal of clinical hypertension (Greenwich, Conn.), Vol.16(1), pp.47-53
01/01/2014
DOI: 10.1111/jch.12218
PMCID: PMC8031874
PMID: 24410943
Abstract
Overactivity of the epithelial sodium channel (ENaC) is considered to be one mechanism underlying obesity-related blood pressure (BP) elevation. In an open-labeled, nonplacebo-controlled clinical trial (Clinicaltrials.gov: NCT-01308983), the authors aimed to comprehensively evaluate the effects of amiloride monotherapy, an ENaC blocker, on BP and cardiovascular risk in young adults with prehypertension (n=17). The mean body mass index of participants was 28.45 +/- 1.30kg/m(2). Following 10mg daily amiloride for 4weeks, peripheral systolic BP (SBP), central SBP, and carotid-radial pulse wave velocity were significantly reduced by -7.06 +/- 2.25mm Hg, -7.68 +/- 2.56mm Hg, and -0.72 +/- 0.33m/s, respectively, whereas flow-mediated dilation was significantly increased by 2.2 +/- 0.9%. Following amiloride monotherapy for 4weeks, a significant increase in serum aldosterone was observed (5.85 +/- 2.45ng/dL). ENaC inhibition by amiloride may be used as an early intervention to halt the progression to full hypertension and cardiovascular disease in young adults with prehypertension.
Details
- Title: Subtitle
- Epithelial Sodium Channel Inhibition by Amiloride on Blood Pressure and Cardiovascular Disease Risk in Young Prehypertensives
- Creators
- Jigar Bhagatwala - Augusta UniversityRyan A. Harris - Augusta UniversitySamip J. Parikh - Augusta UniversityHaidong Zhu - Augusta UniversityYing Huang - Augusta UniversityIshita Kotak - Augusta UniversityNichole Seigler - Augusta UniversityGary L. Pierce - Augusta UniversityBrent M. Egan - Medical University of South CarolinaYanbin Dong - Augusta University
- Resource Type
- Journal article
- Publication Details
- The journal of clinical hypertension (Greenwich, Conn.), Vol.16(1), pp.47-53
- Publisher
- Wiley
- DOI
- 10.1111/jch.12218
- PMID
- 24410943
- PMCID
- PMC8031874
- ISSN
- 1524-6175
- eISSN
- 1751-7176
- Number of pages
- 7
- Grant note
- L077230 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Diabetes and Obesity Discovery Institute of GRU
- Language
- English
- Date published
- 01/01/2014
- Academic Unit
- Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984267247002771
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