Epitheliotropic lymphoma of the small bowel: report of a fatal case with cytotoxic/suppressor T-cell immunotype

Kathy Foucar; Elliott Foucar; Frank Mitros; Gerald Clamon; James Goeken; Judith Crossett

doi:10.1002/1097-0142(19840701)54:1<54::AID-CNCR2820540113>3.0.CO;2-A

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Epitheliotropic lymphoma of the small bowel: report of a fatal case with cytotoxic/suppressor T-cell immunotype

Journal article

Peer reviewed

Epitheliotropic lymphoma of the small bowel: report of a fatal case with cytotoxic/suppressor T-cell immunotype

Kathy Foucar, Elliott Foucar, Frank Mitros, Gerald Clamon, James Goeken and Judith Crossett

Cancer, Vol.54(1), pp.54-60

1984

DOI: 10.1002/1097-0142(19840701)54:1<54::AID-CNCR2820540113>3.0.CO;2-A

PMID: 6232997

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Abstract

Case report The authors report the clinical, pathologic, and immunologic features of a case of jejunal cytotoxic/suppressor T-cell lymphoma associated with intractable malabsorption. Histologically, the tumor exhibited striking involvement of small bowel surface and glandular epithelium, and of epithelium in sites of disease dissemination. This epitheliotropism consisted of both cell clusters resembling Pautrier 's microabscesses and single cells within epithelium. Grossly, the jejunal mucosal fold pattern was completely obliterated by lymphoma which formed miliary nodules and multiple distinct tumor masses. Despite aggressive chemotherapy the patient developed widespread disease, and died 11 months after presentation. At autopsy, in addition to disseminated lymphoma, there was a notable activation of hematopoiesis evidenced by extensive extramedullary hematopoiesis and bone marrow hypercellularity. Many lymph nodes spared by the lymphoma showed a polyclonal proliferation of plasma cells and immunoblasts. In view of recent immunologic evidence that normal cytotoxic/suppressor T-cells selectively home to the gut surface epithelium, striking tumor cell epitheliotropism may be a morphologic marker for visceral lymphomas of cytotoxic/suppressor T-cell origin. This unique case broadens the clinical and morphologic spectrum of T-cell disorders.

Tumors

Biological and medical sciences

Gastroenterology. Liver. Pancreas. Abdomen

Medical sciences

Stomach. Duodenum. Small intestine. Colon. Rectum. Anus

Details

Title: Subtitle: Epitheliotropic lymphoma of the small bowel: report of a fatal case with cytotoxic/suppressor T-cell immunotype
Creators: Kathy Foucar - Univ. Iowa, internal medicine, Iowa City IA 52242, United States
Elliott Foucar - Univ. Iowa, internal medicine, Iowa City IA 52242, United States
Frank Mitros - Univ. Iowa, internal medicine, Iowa City IA 52242, United States
Gerald Clamon - Univ. Iowa, internal medicine, Iowa City IA 52242, United States
James Goeken - Univ. Iowa, internal medicine, Iowa City IA 52242, United States
Judith Crossett - Univ. Iowa, internal medicine, Iowa City IA 52242, United States
Resource Type: Journal article
Publication Details: Cancer, Vol.54(1), pp.54-60
Publisher: Wiley-Liss
DOI: 10.1002/1097-0142(19840701)54:1<54::AID-CNCR2820540113>3.0.CO;2-A
PMID: 6232997
ISSN: 0008-543X
eISSN: 1097-0142
Language: English
Date published: 1984
Academic Unit: Psychiatry; Hematology, Oncology, and Blood & Marrow Transplantation; Pathology; Internal Medicine
Record Identifier: 9984203945702771

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