Journal article
Epitope Spreading: Lessons From Autoimmune Skin Diseases
Journal of investigative dermatology, Vol.110(2), pp.103-109
02/1998
DOI: 10.1046/j.1523-1747.1998.00107.x
PMID: 9457902
Abstract
Autoimmune diseases are initiated when patients develop aberrant T and/or B cell responses against self proteins. These responses presumably are directed to single immunogenic epitopes on these proteins. Recent data in animal models of autoimmune diseases suggest that the targets of immune responses in autoimmunity do not remain fixed, but can be extended to include other epitopes on the same protein or other proteins in the same tissue, a phenomenon termed “epitope spreading.” The “epitope spreading” phenomenon also applies to situations in which tissue damage from a primary inflammatory process causes the release and exposure of a previously “sequestered” antigen, leading to a secondary autoimmune response against the newly released antigen. In experimental autoimmune animal diseases, “epitope spreading” seems to have significant physiologic importance in determining the course and duration of disease. In this paper, we review the current concepts in animal models of autoimmune diseases in order to define the “epitope spreading” phenomenon, and we then propose how this phenomenon might play a significant role in the development and the course of autoimmune skin diseases. Hopefully, an understanding of “epitope spreading” will help the dermatology community to better understand the pathogenesis of autoimmune skin diseases and to rationally fashion disease-specific immune therapy in the future.
Details
- Title: Subtitle
- Epitope Spreading: Lessons From Autoimmune Skin Diseases
- Creators
- Lawrence S Chan - Medicine Service, Section of Dermatology, Lakeside Division, VA Chicago Health Care System, Chicago, Illinois, U.SCarol J Vanderlugt - Department of Microbiology and Immunology, Northwestern University Medical School, Chicago, Illinois, U.S.ATakashi Hashimoto - Department of Dermatology, Kurume University School of Medicine, Kurume, JapanTakeji Nishikawa - Department of Dermatology, Keio University School of Medicine, Tokyo, JapanJohn J Zone - Medicine Service, Section of Dermatology, Salt Lake City VA Medical Center, Salt Lake City, Utah, U.S.AMartin M Black - Department of Dermatopathology, Guy's and St. Thomas Medical and Dental School, London, U.KFenella Wojnarowska - Department of Dermatology, The Oxford Radcliffe Hospital, Oxford, U.KSeth R Stevens - Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, Ohio, U.S.AMei Chen - Department of Dermatology, Northwestern University Medical School, Chicago, Illinois, U.S.AJanet A Fairley - Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.ADavid T Woodley - Medicine Service, Section of Dermatology, Lakeside Division, VA Chicago Health Care System, Chicago, Illinois, U.SStephen D Miller - Department of Microbiology and Immunology, Northwestern University Medical School, Chicago, Illinois, U.S.AKenneth B Gordon - Department of Dermatology, Northwestern University Medical School, Chicago, Illinois, U.S.A
- Resource Type
- Journal article
- Publication Details
- Journal of investigative dermatology, Vol.110(2), pp.103-109
- DOI
- 10.1046/j.1523-1747.1998.00107.x
- PMID
- 9457902
- NLM abbreviation
- J Invest Dermatol
- ISSN
- 0022-202X
- eISSN
- 1523-1747
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 02/1998
- Academic Unit
- Dermatology
- Record Identifier
- 9984025681702771
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