Epstein-Barr Virus Immediate-Early Protein BZLF1 Inhibits Tumor Necrosis Factor Alpha-Induced Signaling and Apoptosis by Downregulating Tumor Necrosis Factor Receptor 1

Thomas E Morrison; Amy Mauser; Aloysius Klingelhutz; Shannon C Kenney

doi:10.1128/JVI.78.1.544-549.2004

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Epstein-Barr Virus Immediate-Early Protein BZLF1 Inhibits Tumor Necrosis Factor Alpha-Induced Signaling and Apoptosis by Downregulating Tumor Necrosis Factor Receptor 1

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Epstein-Barr Virus Immediate-Early Protein BZLF1 Inhibits Tumor Necrosis Factor Alpha-Induced Signaling and Apoptosis by Downregulating Tumor Necrosis Factor Receptor 1

Thomas E Morrison, Amy Mauser, Aloysius Klingelhutz and Shannon C Kenney

Journal of virology, Vol.78(1), pp.544-549

01/2004

DOI: 10.1128/JVI.78.1.544-549.2004

PMCID: PMC303403

PMID: 14671137

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Abstract

Tumor necrosis factor alpha (TNF-α) is a key mediator of host immune and inflammatory responses and inhibits herpesvirus replication by cytolytic and noncytolytic mechanisms. TNF-α effects are primarily mediated through the major TNF-α receptor, TNF-R1, which is constitutively expressed in most cell types. Here we show that the Epstein-Barr virus (EBV) immediate-early protein BZLF1 prevents TNF-α activation of target genes and TNF-α-induced cell death. These effects are mediated by down-regulation of the promoter for TNF-R1. Additionally, we demonstrate that expression of TNF-R1 is downregulated during the EBV lytic replication cycle. Thus, EBV has developed a novel mechanism for evading TNF-α antiviral effects during lytic reactivation or primary infection.

Virus-Cell Interactions

Details

Title: Subtitle: Epstein-Barr Virus Immediate-Early Protein BZLF1 Inhibits Tumor Necrosis Factor Alpha-Induced Signaling and Apoptosis by Downregulating Tumor Necrosis Factor Receptor 1
Creators: Thomas E Morrison - Department of Microbiology, University of Iowa, Iowa City, Iowa 52242
Amy Mauser - Department of Microbiology, University of Iowa, Iowa City, Iowa 52242
Aloysius Klingelhutz - Department of Microbiology, University of Iowa, Iowa City, Iowa 52242
Shannon C Kenney - Department of Microbiology, University of Iowa, Iowa City, Iowa 52242
Resource Type: Journal article
Publication Details: Journal of virology, Vol.78(1), pp.544-549
DOI: 10.1128/JVI.78.1.544-549.2004
PMID: 14671137
PMCID: PMC303403
NLM abbreviation: J Virol
ISSN: 0022-538X
eISSN: 1098-5514
Publisher: American Society for Microbiology
Language: English
Date published: 01/2004
Academic Unit: Microbiology and Immunology; Radiation Oncology
Record Identifier: 9984001229502771

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