Journal article
Epstein-Barr Virus Infections: Biology, Pathogenesis, and Management
Annals of internal medicine, Vol.118(1), p.45
01/01/1993
DOI: 10.1059/0003-4819-118-1-199301010-00009
PMID: 8380053
Abstract
Epstein-Barr virus (EBV) encodes genes that ensure its persistence in human B lymphocytes. Some of the genes encourage B-cell
proliferation; others are poised to evade or defeat immune recognition. Immune restraints on the virus, however, are typically
so effective that most infections are never symptomatic. In contrast, acute infectious mononucleosis, a self-limited lymphoproliferative
illness, is common in adolescents and young adults. Unbridled proliferative illnesses arise when cellular immunity is grossly
defective. Treatment of EBV-associated syndromes is largely supportive. Antiviral drugs have no proven role except in patients
with oral hairy leukoplakia. Vaccine development is technically feasible but is not considered a high priority for developed
nations.
Details
- Title: Subtitle
- Epstein-Barr Virus Infections: Biology, Pathogenesis, and Management
- Creators
- Stephen E Straus - National Institutes of HealthJeffrey I CohenGiovanna TosatoJeffery Meier - University of Iowa, Internal Medicine
- Resource Type
- Journal article
- Publication Details
- Annals of internal medicine, Vol.118(1), p.45
- Publisher
- American College of Physicians
- DOI
- 10.1059/0003-4819-118-1-199301010-00009
- PMID
- 8380053
- ISSN
- 0003-4819
- eISSN
- 1539-3704
- Language
- English
- Date published
- 01/01/1993
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9984094671402771
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