Epstein-Barr virus-associated gastric carcinoma in Japanese Brazilians and non-Japanese Brazilians in São Paulo

Chihaya Koriyama; Suminori Akiba; Kiyoshi Iriya; Thiana Yamaguti; Gerson S. Hamada; Tetsuhiko Itoh; Yoshito Eizuru; Takashi Aikou; Shaw Watanabe; Shoichiro Tsugane; Masayoshi Tokunaga

doi:10.1111/j.1349-7006.2001.tb01180.x

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Epstein-Barr virus-associated gastric carcinoma in Japanese Brazilians and non-Japanese Brazilians in São Paulo

Journal article

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Epstein-Barr virus-associated gastric carcinoma in Japanese Brazilians and non-Japanese Brazilians in São Paulo

Chihaya Koriyama, Suminori Akiba, Kiyoshi Iriya, Thiana Yamaguti, Gerson S. Hamada, Tetsuhiko Itoh, Yoshito Eizuru, Takashi Aikou, Shaw Watanabe, Shoichiro Tsugane, …

Japanese journal of cancer research (Gann), Vol.92(9), pp.911-917

2001

DOI: 10.1111/j.1349-7006.2001.tb01180.x

PMID: 11572757

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Abstract

The proportion of Epstein-Barr virus-associated gastric carcinoma (EB V-GC) was examined in 149 Japanese-Brazilian and 151 non-Japanese-Brazilian gastric-carcinoma cases using in situ hybridization (ISH) assay to detect EBV-encoded small RNA (EBER), and the results were compared with our referent Japanese data. We found that 4.7% of cases in Japanese Brazilians were EBER-positive. This frequency was slightly lower than that of the referent Japanese, among whom 6.2% of 2038 gastric-carcinoma cases were EBER-positive. On the other hand, the non-Japanese-Brazilian series showed a significantly higher proportion of EBV-GC (11.2%) than the referent group did (P=0.01). Although EBV-GC was predominant in males among non-Japanese Brazilians (M/ F=3.6, P=0.047), as was the case in Japanese (M/F=2.7), Japanese Brazilians did not show such a male predominance. The sex-ratio difference between the Japanese Brazilians and Japanese was statistically significant (P=0.005). In conclusion, the present study in Japanese Brazilians and Japanese yielded no evidence suggesting any change in the frequency of EBV-GC caused by migration, except the absence of male predominance, which was observed both in Japanese and non-Japanese Brazilians.

Brazil

Epstein-Barr Virus

Gastric carcinoma

Japanese immigrants

Details

Title: Subtitle: Epstein-Barr virus-associated gastric carcinoma in Japanese Brazilians and non-Japanese Brazilians in São Paulo
Creators: Chihaya Koriyama - Kagoshima University
Suminori Akiba - Kagoshima University
Kiyoshi Iriya - Universidade de São Paulo
Thiana Yamaguti - Hospital Santa Paula
Gerson S. Hamada - Hospital Santa Paula
Tetsuhiko Itoh - Kagoshima Medical Center
Yoshito Eizuru - Kagoshima University
Takashi Aikou - Kagoshima University
Shaw Watanabe - Tokyo University of Agriculture
Shoichiro Tsugane - National Cancer Center Hospital East
Masayoshi Tokunaga - Kodama Hospital, Japan
Resource Type: Journal article
Publication Details: Japanese journal of cancer research (Gann), Vol.92(9), pp.911-917
DOI: 10.1111/j.1349-7006.2001.tb01180.x
PMID: 11572757
ISSN: 0910-5050
Publisher: JAPANESE CANCER ASSOC
Language: English
Date published: 2001
Academic Unit: Anesthesia
Record Identifier: 9985214171002771

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