Journal article
Epstein-Barr virus patterns in US Burkitt lymphoma tumors from the SEER residual tissue repository during 1979-2009
APMIS : acta pathologica, microbiologica et immunologica Scandinavica, Vol.122(1), pp.5-15
01/2014
DOI: 10.1111/apm.12078
PMCID: PMC3723754
PMID: 23607450
Abstract
Burkitt lymphoma (BL) occurs at all ages, but the patterns of Epstein-Barr virus (EBV) positivity in relation to human immunodeficiency virus (HIV), immunoprofiles and age have not been fully explored. BL tissues from residual tissue repositories, and two academic centers in the United States were examined by expert hematopathologists for morphology, immunohistochemistry, MYC rearrangement, EBV-encoded RNA (EBER), and diagnosed according to the 2008 WHO lymphoma classification. Analysis was done using frequency tables, Chi-squared statistics, and Student's t-test. Of 117 cases examined, 91 were confirmed as BL. The age distribution was 26%, 15%, 19%, and 29% for 0-19, 20-34, 35-59, 60+ years, and missing in 11%. MYC rearrangement was found in 89% and EBER positivity in 29% of 82 cases with results. EBER positivity varied with age (from 13% in age group 0-19 to 55% in age group 20-34, and fell to 25% in age group 60+ years, p = 0.08); with race (56% in Blacks/Hispanics vs 21% in Whites/Asians/Pacific Islanders, p = 0.006); and by HIV status (64% in HIV positive vs 22% in HIV negative cases, p = 0.03). EBER positivity was demonstrated in about one-third of tumors and it was strongly associated with race and HIV status, and marginally with age-group.
Details
- Title: Subtitle
- Epstein-Barr virus patterns in US Burkitt lymphoma tumors from the SEER residual tissue repository during 1979-2009
- Creators
- Sam M Mbulaiteye - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USASheeja T PullarkatBharat N NathwaniLawrence M WeissNagesh RaoBenjamin EmmanuelCharles F LynchBrenda HernandezVishala NeppalliDebra HawesMyles G CockburnAndre KimMakeda WilliamsSean AltekruseKishor BhatiaMarc T GoodmanWendy Cozen
- Resource Type
- Journal article
- Publication Details
- APMIS : acta pathologica, microbiologica et immunologica Scandinavica, Vol.122(1), pp.5-15
- DOI
- 10.1111/apm.12078
- PMID
- 23607450
- PMCID
- PMC3723754
- NLM abbreviation
- APMIS
- ISSN
- 1600-0463
- eISSN
- 1600-0463
- Publisher
- Denmark
- Grant note
- U58 DP000807 / NCCDPHP CDC HHS 1U58DP000807-3 / NCCDPHP CDC HHS HHSN261200900586P / PHS HHS N01PC35143 / NCI NIH HHS N01-PC-35137 / NCI NIH HHS N01-PC-35139 / NCI NIH HHS N01-PC-2010-00035 / NCI NIH HHS HHSN261200900444P / PHS HHS P30 CA086862 / NCI NIH HHS N01PC35137 / NCI NIH HHS ZIA CP010150-010 / Intramural NIH HHS N01-PC-35143 / NCI NIH HHS
- Language
- English
- Date published
- 01/2014
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995033102771
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