Journal article
Erythrocyte Incorporation of Ingested 58-Iron by Infants
Pediatric research, Vol.24(1), pp.20-24
07/1988
DOI: 10.1203/00006450-198807000-00006
PMID: 3412846
Abstract
The least abundant stable isotope of iron, 58Fe (natural abundance 0.322 weight %), was administered orally to infants to explore the feasibility of using a stable rather than a radioisotope in studies of iron absorption. The dose of 58Fe was given between feedings at age 126 days. The mass isotope ratio, 58Fe/57Fe, was determined in blood by inductively coupled plasma mass spectroscopy and at ages 140, 168, and 196 days. The percentage of the 58Fe dose entering the circulation (3.2 to 16.0%) was inversely correlated with serum ferritin concentration (r = −0.867, p < 0.01). For individual infants the SD of the percentage of administered dose of iron appearing in the circulation ranged from 0.22 to 1.28. We conclude that the method is likely to be suitable for within-subject comparisons of iron availability from foods. Because of the large between-subject variation, we are pessimistic for this age group about the usefulness of study designs based on group comparisons.
Details
- Title: Subtitle
- Erythrocyte Incorporation of Ingested 58-Iron by Infants
- Creators
- Samuel J FomonMorteza JanghorbaniBill T G TingEkhard E ZieglerRonald R RogersSteven E NelsonLynda S OstedgaardBarbara B Edwards
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.24(1), pp.20-24
- DOI
- 10.1203/00006450-198807000-00006
- PMID
- 3412846
- NLM abbreviation
- Pediatr Res
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Language
- English
- Date published
- 07/1988
- Academic Unit
- Stead Family Department of Pediatrics; Internal Medicine
- Record Identifier
- 9984094505402771
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