Journal article
Establishment of a reference interval for β2-microglobulin in cerebrospinal fluid with use of two commercial assays
Clinical chemistry (Baltimore, Md.), Vol.37(1), pp.104-107
1991
DOI: 10.1093/clinchem/37.1.104
PMID: 1988188
Abstract
Increased concentrations of β2-microglobulin in cerebrospinal fluid have been used to detect central nervous system involvement with metastatic cancer and with neurological complications of AIDS. However, no adequate reference interval study has been reported for β2-microglobulin in cerebrospinal fluid. We established a reference interval with both the Abbott IMx microparticle enzyme-linked immunoassay (EIA) (0.6-2.0 mg/L) and the Pharmacia β2-micro EIA 96 method (0.8-2.2 mg/L) for β2-microglobulin in cerebrospinal fluid. The two methods correlate well, with the latter method giving slightly higher values. β2-Microglobulin increases with age in adults by about 0.1 mg/L every 7.5 years, with no significant difference between genders.
Details
- Title: Subtitle
- Establishment of a reference interval for β2-microglobulin in cerebrospinal fluid with use of two commercial assays
- Creators
- C. T Lutz - Univ. Iowa, dep. pathology, Iowa city IA 52242, United StatesS. H Cornell - Univ. Iowa, dep. pathology, Iowa city IA 52242, United StatesJ. A Goeken - Univ. Iowa, dep. pathology, Iowa city IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- Clinical chemistry (Baltimore, Md.), Vol.37(1), pp.104-107
- Publisher
- American Association for Clinical Chemistry
- DOI
- 10.1093/clinchem/37.1.104
- PMID
- 1988188
- ISSN
- 0009-9147
- eISSN
- 1530-8561
- Language
- English
- Date published
- 1991
- Academic Unit
- Pathology
- Record Identifier
- 9984204114502771
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