Estimate of infant HIV-free survival at 6 to 8 weeks of age due to maternal antiretroviral prophylaxis in Sub-Saharan Africa, 2004-2005

Caroline E Boeke; J Brooks Jackson

doi:10.1177/1545109708318517

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Estimate of infant HIV-free survival at 6 to 8 weeks of age due to maternal antiretroviral prophylaxis in Sub-Saharan Africa, 2004-2005

Journal article

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Estimate of infant HIV-free survival at 6 to 8 weeks of age due to maternal antiretroviral prophylaxis in Sub-Saharan Africa, 2004-2005

Caroline E Boeke and J Brooks Jackson

Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002), Vol.7(3), pp.133-140

05/2008

DOI: 10.1177/1545109708318517

PMID: 18460695

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Abstract

The objective of this study is to estimate the number of infants alive and HIV-free at 6 to 8 weeks in sub-Saharan Africa due to intervention with antiretroviral prophylaxis to prevent mother-to-child transmission. The number of additional uninfected live infants at 6 to 8 weeks of age due to prophylaxis was calculated using prevalence and prophylaxis data from the World Health Organization and United Nations Children's Fund and data on the efficacy of nevirapine and birth and mortality rates among infants of infected mothers who received prophylaxis in sub-Saharan Africa. Approximately 31 474 African infants were spared from HIV infection or death by 6 to 8 weeks of age due to prophylaxis in 2004 and 2005. The number of infections and deaths averted per year increased from 13 710 in 2004 to 17 764 in 2005. The estimated number of infant HIV infections and deaths averted in 2004 and 2005 due to prophylaxis is encouraging.

Pregnancy Complications, Infectious - virology

World Health Organization

Infant Mortality

Chemoprevention

HIV Infections - epidemiology

Humans

United Nations

Infant

Nevirapine - therapeutic use

Survival Rate

Pregnancy

Pregnancy Complications, Infectious - prevention & control

Anti-HIV Agents - therapeutic use

Female

HIV Infections - drug therapy

HIV Infections - mortality

HIV Infections - transmission

Reverse Transcriptase Inhibitors - therapeutic use

Africa South of the Sahara - epidemiology

Infectious Disease Transmission, Vertical - prevention & control

Details

Title: Subtitle: Estimate of infant HIV-free survival at 6 to 8 weeks of age due to maternal antiretroviral prophylaxis in Sub-Saharan Africa, 2004-2005
Creators: Caroline E Boeke - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
J Brooks Jackson
Resource Type: Journal article
Publication Details: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002), Vol.7(3), pp.133-140
DOI: 10.1177/1545109708318517
PMID: 18460695
NLM abbreviation: J Int Assoc Physicians AIDS Care (Chic)
ISSN: 1545-1097
eISSN: 1557-0886
Publisher: United States
Language: English
Date published: 05/2008
Academic Unit: Pathology; VPMA - Administration
Record Identifier: 9984047798802771

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