Journal article
Estimated Aortic Stiffness is Independently Associated with Cardiac Baroreflex Sensitivity in Humans: Role of Aging and Habitual Endurance Exercise
Journal of human hypertension, Vol.30(9), pp.513-520
09/2016
DOI: 10.1038/jhh.2016.3
PMCID: PMC4981524
PMID: 26911535
Abstract
We hypothesized that differences in cardiac baroreflex sensitivity (BRS) would be independently associated with aortic stiffness and augmentation index (AI), clinical biomarkers of cardiovascular disease (CVD) risk, among young sedentary and middle-aged/older sedentary and endurance-trained adults. A total of 36 healthy middle-aged/older (age 55-76 years, n=22 sedentary; n=14 endurance-trained) and 5 young sedentary (age 18-31 years) adults were included in a cross-sectional study. A subset of the middle-aged/older sedentary adults (n=12) completed an 8-week aerobic exercise intervention. Invasive brachial artery blood pressure waveforms were used to compute spontaneous cardiac BRS (via sequence technique) and estimated aortic pulse wave velocity (PWV) and AI (AI, via brachial-aortic transfer function and wave separation analysis). In the cross-sectional study, cardiac BRS was 71% lower in older compared with young sedentary adults (P<0.05), but only 40% lower in older adults who performed habitual endurance exercise (P=0.03). In a regression model that included age, sex, resting heart rate, mean arterial pressure (MAP), body mass index and maximal exercise oxygen uptake, estimated aortic PWV (β±SE = −5.76 ± 2.01, P=0.01) was the strongest predictor of BRS (Model R
2
=0.59, P<0.001). The 8 week exercise intervention improved BRS by 38% (P=0.04) and this change in BRS was associated with improved aortic PWV (r=−0.65, P=0.044, adjusted for changes in MAP). Age- and endurance exercise-related differences in cardiac BRS are independently associated with corresponding alterations in aortic PWV among healthy adults, consistent with a mechanistic link between variations in the sensitivity of the baroreflex and aortic stiffness with age and exercise.
Details
- Title: Subtitle
- Estimated Aortic Stiffness is Independently Associated with Cardiac Baroreflex Sensitivity in Humans: Role of Aging and Habitual Endurance Exercise
- Creators
- Gary L Pierce - Department of Integrative Physiology, University of Colorado Boulder, Boulder, COStephen A Harris - Department of Integrative Physiology, University of Colorado Boulder, Boulder, CODouglas R Seals - Department of Integrative Physiology, University of Colorado Boulder, Boulder, CODarren P Casey - Department of Integrative Physiology, University of Colorado Boulder, Boulder, COPatrick B Barlow - Department of Integrative Physiology, University of Colorado Boulder, Boulder, COHarald M Stauss - Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO
- Resource Type
- Journal article
- Publication Details
- Journal of human hypertension, Vol.30(9), pp.513-520
- DOI
- 10.1038/jhh.2016.3
- PMID
- 26911535
- PMCID
- PMC4981524
- ISSN
- 0950-9240
- eISSN
- 1476-5527
- Language
- English
- Date published
- 09/2016
- Academic Unit
- Center for Social Science Innovation; Physical Therapy and Rehabilitation Science; Office of Consultation and Research in Medical Education; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984001105002771
Metrics
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