Estimated Ventricular Size, Asthma Severity, and Exacerbations: The Severe Asthma Research Program III Cohort

Samuel Y Ash; Gonzalo Vegas Sanchez-Ferrero; Mark L Schiebler; Farbod N Rahaghi; Ashish Rai; Carolyn E Come; James C Ross; Alysha G Colon; Juan Carlos Cardet; Eugene R Bleecker; Mario Castro; John V Fahy; Sean B Fain; Benjamin M Gaston; Eric A Hoffman; Nizar N Jarjour; Jason K Lempel; David T Mauger; Matthew C Tattersall; Sally E Wenzel; Bruce D Levy; George R Washko; Elliot Israel; Raul San Jose Estepar; SARP Investigators

doi:10.1016/j.chest.2019.08.2185

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Estimated Ventricular Size, Asthma Severity, and Exacerbations: The Severe Asthma Research Program III Cohort

Journal article

Open access

Peer reviewed

Estimated Ventricular Size, Asthma Severity, and Exacerbations: The Severe Asthma Research Program III Cohort

Samuel Y Ash, Gonzalo Vegas Sanchez-Ferrero, Mark L Schiebler, Farbod N Rahaghi, Ashish Rai, Carolyn E Come, James C Ross, Alysha G Colon, Juan Carlos Cardet, Eugene R Bleecker, …

Chest, Vol.157(2), pp.258-267

02/2020

DOI: 10.1016/j.chest.2019.08.2185

PMCID: PMC7005378

PMID: 31521672

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https://doi.org/10.1016/j.chest.2019.08.2185View

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Abstract

Relative enlargement of the pulmonary artery (PA) on chest CT imaging is associated with respiratory exacerbations in patients with COPD or cystic fibrosis. We sought to determine whether similar findings were present in patients with asthma and whether these findings were explained by differences in ventricular size. We measured the PA and aorta diameters in 233 individuals from the Severe Asthma Research Program III cohort. We also estimated right, left, and total epicardial cardiac ventricular volume indices (eERVVI, eELVVI, and eETVVI, respectively). Associations between the cardiac and PA measures (PA-to-aorta [PA/A] ratio, eERVVI-to-eELVVI [eRV/eLV] ratio, eERVVI, eELVVI, eETVVI) and clinical measures of asthma severity were assessed by Pearson correlation, and associations with asthma severity and exacerbation rate were evaluated by multivariable linear and zero-inflated negative binomial regression. Asthma severity was associated with smaller ventricular volumes. For example, those with severe asthma had 36.1 mL/m smaller eETVVI than healthy control subjects (P = .003) and 14.1 mL/m smaller eETVVI than those with mild/moderate disease (P = .011). Smaller ventricular volumes were also associated with a higher rate of asthma exacerbations, both retrospectively and prospectively. For example, those with an eETVVI less than the median had a 57% higher rate of exacerbations during follow-up than those with eETVVI greater than the median (P = .020). Neither PA/A nor eRV/eLV was associated with asthma severity or exacerbations. In patients with asthma, smaller cardiac ventricular size may be associated with more severe disease and a higher rate of asthma exacerbations. ClinicalTrials.gov; No.: NCT01761630; URL: www.clinicaltrials.gov.

Adult

Aorta - diagnostic imaging

Aorta - pathology

Asthma - diagnostic imaging

Asthma - physiopathology

Case-Control Studies

Cone-Beam Computed Tomography

Disease Progression

Female

Forced Expiratory Volume

Heart Ventricles - diagnostic imaging

Heart Ventricles - pathology

Humans

Logistic Models

Male

Middle Aged

Organ Size

Pulmonary Artery - diagnostic imaging

Pulmonary Artery - pathology

Severity of Illness Index

Vital Capacity

Details

Title: Subtitle: Estimated Ventricular Size, Asthma Severity, and Exacerbations: The Severe Asthma Research Program III Cohort
Creators: Samuel Y Ash - Brigham and Women's Hospital
Gonzalo Vegas Sanchez-Ferrero - Brigham and Women's Hospital
Mark L Schiebler - University of Wisconsin–Madison
Farbod N Rahaghi - Brigham and Women's Hospital
Ashish Rai - North Shore Medical Center
Carolyn E Come - Brigham and Women's Hospital
James C Ross - Brigham and Women's Hospital
Alysha G Colon - University of Florida
Juan Carlos Cardet - University of South Florida
Eugene R Bleecker - University of Arizona
Mario Castro - Washington University in St. Louis
John V Fahy - University of California, San Francisco
Sean B Fain - University of Wisconsin–Madison
Benjamin M Gaston - Boston Children's Hospital
Eric A Hoffman - University of Iowa
Nizar N Jarjour - University of Wisconsin–Madison
Jason K Lempel - Cleveland Clinic
David T Mauger - Pennsylvania State University
Matthew C Tattersall - University of Wisconsin–Madison
Sally E Wenzel - University of Pittsburgh
Bruce D Levy - Brigham and Women's Hospital
George R Washko - Brigham and Women's Hospital
Elliot Israel - Brigham and Women's Hospital
Raul San Jose Estepar - Brigham and Women's Hospital
SARP Investigators
Resource Type: Journal article
Publication Details: Chest, Vol.157(2), pp.258-267
DOI: 10.1016/j.chest.2019.08.2185
PMID: 31521672
PMCID: PMC7005378
ISSN: 0012-3692
eISSN: 1931-3543
Grant note: T32 HL007633 / NHLBI NIH HHS U10 HL109146 / NHLBI NIH HHS R01 HL116931 / NHLBI NIH HHS U01 HL146002 / NHLBI NIH HHS K23 HL114735 / NHLBI NIH HHS UL1 TR001102 / NCATS NIH HHS U10 HL109250 / NHLBI NIH HHS R01 HL122531 / NHLBI NIH HHS UL1 TR000448 / NCATS NIH HHS UL1 TR002373 / NCATS NIH HHS U10 HL109257 / NHLBI NIH HHS K23 AI125785 / NIAID NIH HHS U10 HL109164 / NHLBI NIH HHS UL1 TR000427 / NCATS NIH HHS U10 HL109172 / NHLBI NIH HHS UL1 TR002345 / NCATS NIH HHS L30 HL134158 / NHLBI NIH HHS R01 HL122464 / NHLBI NIH HHS U10 HL109086 / NHLBI NIH HHS U10 HL109168 / NHLBI NIH HHS S10 OD018526 / NIH HHS K23 HL136905 / NHLBI NIH HHS K08 HL145118 / NHLBI NIH HHS U10 HL109152 / NHLBI NIH HHS R01 HL116473 / NHLBI NIH HHS P30 DK054759 / NIDDK NIH HHS UL1 TR001420 / NCATS NIH HHS
Language: English
Date published: 02/2020
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health and Human Physiology; Internal Medicine
Record Identifier: 9984275055702771

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