Estimating Premorbid Functioning in Huntington's Disease: The Relationship between Disease Progression and the Wide Range Achievement Test Reading Subtest

Justin J.F O'Rourke; William H Adams; Kevin Duff; Joanne Byars; Peg Nopoulos; Jane S Paulsen; Leigh J Beglinger

doi:10.1093/arclin/acq088

Back

Estimating Premorbid Functioning in Huntington's Disease: The Relationship between Disease Progression and the Wide Range Achievement Test Reading Subtest

Journal article

Open access

Peer reviewed

Estimating Premorbid Functioning in Huntington's Disease: The Relationship between Disease Progression and the Wide Range Achievement Test Reading Subtest

Justin J.F O'Rourke, William H Adams, Kevin Duff, Joanne Byars, Peg Nopoulos, Jane S Paulsen and Leigh J Beglinger

Archives of clinical neuropsychology, Vol.26(1), pp.59-66

02/2011

DOI: 10.1093/arclin/acq088

PMCID: PMC3021970

PMID: 21147861

Files and links (1)

url

https://doi.org/10.1093/arclin/acq088View

Published (Version of record) Open Access

Abstract

The estimation of premorbid abilities is an essential part of a neuropsychological evaluation, especially in neurodegenerative conditions. Although word pronunciation tests are one standard method for estimating the premorbid level, research suggests that these tests may not be valid in neurodegenerative diseases. Therefore, the current study sought to examine two estimates of premorbid intellect, the Wide Range Achievement Test (WRAT) Reading subtest and the Barona formula, in 93 patients with mild to moderate Huntington's disease (HD) to determine their utility and to investigate how these measures relate to signs and symptoms of disease progression. In 89% of participants, WRAT estimates were below the Barona estimates. WRAT estimates were related to worsening memory and motor functioning, whereas the Barona estimates had weaker relationships. Neither estimate was related to depression or functional capacity. Irregular word reading tests appear to decline with HD progression, whereas estimation methods based on demographic factors may be more robust but overestimate premorbid functioning.

assessment

dementia

basal ganglia

movement disorders

Original Empirical

Huntington's disease

Details

Title: Subtitle: Estimating Premorbid Functioning in Huntington's Disease: The Relationship between Disease Progression and the Wide Range Achievement Test Reading Subtest
Creators: Justin J.F O'Rourke - ,
William H Adams - ,
Kevin Duff - ,
Joanne Byars - ,
Peg Nopoulos - ,
Jane S Paulsen - ,
Leigh J Beglinger - ,
Resource Type: Journal article
Publication Details: Archives of clinical neuropsychology, Vol.26(1), pp.59-66
DOI: 10.1093/arclin/acq088
PMID: 21147861
PMCID: PMC3021970
NLM abbreviation: Arch Clin Neuropsychol
ISSN: 0887-6177
eISSN: 1873-5843
Publisher: Oxford University Press
Language: English
Date published: 02/2011
Academic Unit: Neurology; Psychiatry; Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984003939302771

Metrics

31 Record Views

17 Times Cited - Web of Science