Estimation of Current and Future Physiological States in Insular Cortex

Yoav Livneh; Arthur U Sugden; Joseph C Madara; Rachel A Essner; Vanessa I Flores; Lauren A Sugden; Jon M Resch; Bradford B Lowell; Mark L Andermann

doi:10.1016/j.neuron.2019.12.027

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Estimation of Current and Future Physiological States in Insular Cortex

Journal article

Peer reviewed

Estimation of Current and Future Physiological States in Insular Cortex

Yoav Livneh, Arthur U Sugden, Joseph C Madara, Rachel A Essner, Vanessa I Flores, Lauren A Sugden, Jon M Resch, Bradford B Lowell and Mark L Andermann

Neuron (Cambridge, Mass.), Vol.105(6), pp.1094-1111.e10

03/18/2020

DOI: 10.1016/j.neuron.2019.12.027

PMCID: PMC7083695

PMID: 31955944

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https://www.ncbi.nlm.nih.gov/pmc/articles/7083695View

Open Access

Abstract

Interoception, the sense of internal bodily signals, is essential for physiological homeostasis, cognition, and emotions. While human insular cortex (InsCtx) is implicated in interoception, the cellular and circuit mechanisms remain unclear. We imaged mouse InsCtx neurons during two physiological deficiency states: hunger and thirst. InsCtx ongoing activity patterns reliably tracked the gradual return to homeostasis but not changes in behavior. Accordingly, while artificial induction of hunger or thirst in sated mice via activation of specific hypothalamic neurons (AgRP or SFO ) restored cue-evoked food- or water-seeking, InsCtx ongoing activity continued to reflect physiological satiety. During natural hunger or thirst, food or water cues rapidly and transiently shifted InsCtx population activity to the future satiety-related pattern. During artificial hunger or thirst, food or water cues further shifted activity beyond the current satiety-related pattern. Together with circuit-mapping experiments, these findings suggest that InsCtx integrates visceral-sensory signals of current physiological state with hypothalamus-gated amygdala inputs that signal upcoming ingestion of food or water to compute a prediction of future physiological state.

Cues

Optical Imaging

Interoception - physiology

Hypothalamus - physiology

Male

Mice, Transgenic

Optogenetics

Clozapine - analogs & derivatives

Agouti-Related Protein - metabolism

Neural Pathways - physiology

Thirst - physiology

Clozapine - pharmacology

Animals

Subfornical Organ - physiology

Cerebral Cortex - physiology

Female

Mice

Hunger - physiology

Details

Title: Subtitle: Estimation of Current and Future Physiological States in Insular Cortex
Creators: Yoav Livneh - Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Arthur U Sugden - Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Joseph C Madara - Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Rachel A Essner - Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
Vanessa I Flores - Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Lauren A Sugden - Department of Mathematics and Computer Science, Duquesne University, Pittsburgh, PA 15232, USA
Jon M Resch - Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Bradford B Lowell - Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA. Electronic address: blowell@bidmc.harvard.edu
Mark L Andermann - Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA. Electronic address: manderma@bidmc.harvard.edu
Resource Type: Journal article
Publication Details: Neuron (Cambridge, Mass.), Vol.105(6), pp.1094-1111.e10
DOI: 10.1016/j.neuron.2019.12.027
PMID: 31955944
PMCID: PMC7083695
NLM abbreviation: Neuron
ISSN: 0896-6273
eISSN: 1097-4199
Publisher: United States
Grant note: DP1 AT010971 / NCCIH NIH HHS R01 DK096010 / NIDDK NIH HHS R01 DK111401 / NIDDK NIH HHS R01 DK089044 / NIDDK NIH HHS DP2 DK105570 / NIDDK NIH HHS R01 DK075632 / NIDDK NIH HHS R01 DK109930 / NIDDK NIH HHS P30 DK046200 / NIDDK NIH HHS K99 HL144923 / NHLBI NIH HHS T32 DK007516 / NIDDK NIH HHS P30 DK057521 / NIDDK NIH HHS
Language: English
Date published: 03/18/2020
Academic Unit: Iowa Neuroscience Institute; Neuroscience and Pharmacology
Record Identifier: 9984065853602771

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