Journal article
Estrogen protects aldosterone/NaCl‐induced hypertension in conscious rats
The FASEB journal, Vol.21(6), pp.LB120-LB120
2007
DOI: 10.1096/fasebj.21.6.LB120-b
Abstract
Previous studies from our laboratory have shown that there are sex differences in the development of aldosterone (ALDO)/NaCl‐induced hypertension. The present study was performed to determine which sex hormone is responsible for these sex differences. Male and female Sprague‐Dawley rats were infused subcutaneously with ALDO (0.75 μg/h, 28 days) and 1% NaCl was provided as the sole source of drinking fluid. Aortic blood pressure was measured by DSI® telemetry. ALDO+1% NaCl‐treated male rats progressively developed hypertension (101.6±2.8 to 124.6±3.6, Δ23.2±3.7 mmHg, n=6) but blood pressures in females were not different from the control values (98.4±1.7 to 101.8±3.5, Δ3.4±1.4 mmHg, n=4). Gonadectomy augmented ALDO+1% NaCl‐induced hypertension in females (Δ17.1±2.3 mmHg, n=3) but had no effect in males (Δ20.9±2.2 mmHg, n=4). Moreover, systemic infusion of 17β‐estradiol (250 μg/day) totally blocked ALDO+1% NaCl‐induced hypertension in intact males (Δ‐1.5±2.4 mmHg, n=3). These results indicate that estrogen may play a protective role in the development of ALDO+1% NaCl‐induced hypertension.
(Supported by NIH HL‐59676, HL‐62261, HL‐14388, and DK‐66086.)
Details
- Title: Subtitle
- Estrogen protects aldosterone/NaCl‐induced hypertension in conscious rats
- Creators
- Baojian XueDaniel Badaue‐PassosAlan Kim Johnson - Cardiovascular CenterMeredith Hay - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The FASEB journal, Vol.21(6), pp.LB120-LB120
- Publisher
- The Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.21.6.LB120-b
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Grant note
- NIH (HL‐59676, HL‐62261, HL‐14388, and DK‐66086)
- Language
- English
- Date published
- 2007
- Academic Unit
- Health and Human Physiology; Neuroscience and Pharmacology; Psychological and Brain Sciences; Neurology (Pediatrics)
- Record Identifier
- 9984214754402771
Metrics
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