Journal article
Estrogen regulation of immune responses after injury
Molecular and cellular endocrinology, Vol.193(1), pp.129-135
2002
DOI: 10.1016/S0303-7207(02)00106-5
PMID: 12161012
Abstract
There is a naturally occurring gender difference in immune responses which persists after traumatic injury. Physiological levels of 17β-estradiol (E
2) are immunostimulatory, whereas high pregnancy and superphysiological levels are immunosuppressive. In contrast, at all concentrations, testosterone suppresses immune responses. Evidence from this laboratory and others suggest that the gender difference in immune responses after injury is mediated in part by alterations in the circulating levels of gonadal steroid hormones through modulation of production of inflammatory and immunoregulatory cytokines, including interleukin-6 (IL-6). Aberrant production of IL-6 is known to be an important mediator of immunity after injury. Since E
2 is a critical regulator of IL-6 production and overall immune function, it suggests gender specific therapies should be considered for the treatment of patients.
Details
- Title: Subtitle
- Estrogen regulation of immune responses after injury
- Creators
- Elizabeth J Kovacs - Immunology and Aging Program, Loyola University Chicago, Maywood, IL, USAKelly A.N Messingham - Alcohol Research Program, Loyola University Chicago, Maywood, IL, USAMeredith S Gregory - Burn and Shock Trauma Institute, Loyola University Chicago, Maywood, IL, USA
- Resource Type
- Journal article
- Publication Details
- Molecular and cellular endocrinology, Vol.193(1), pp.129-135
- Publisher
- Elsevier Ireland Ltd
- DOI
- 10.1016/S0303-7207(02)00106-5
- PMID
- 12161012
- ISSN
- 0303-7207
- eISSN
- 1872-8057
- Language
- English
- Date published
- 2002
- Academic Unit
- Dermatology
- Record Identifier
- 9984025578002771
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