Journal article
Etanercept in the treatment of macrophage activation syndrome
Journal of rheumatology, Vol.28(9), pp.2120-2124
2001
PMID: 11550985
Abstract
Macrophage activation syndrome (MAS), a recognized complication of systemic juvenile rheumatoid arthritis (sJRA), has been associated with significant morbidity and mortality. Dysregulation of macrophage-lymphocyte interactions leading to uncontrolled proliferation of highly activated macrophages and massive release of proinflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha) appears to be central to the pathogenesis of this syndrome. Until now the mainstay of therapy has been corticosteroids and cyclosporin A. We describe a patient with MAS and sJRA successfully treated with the anti-TNF agent etanercept. The outcome in this patient suggests etanercept might be an effective therapeutic agent in MAS.
Details
- Title: Subtitle
- Etanercept in the treatment of macrophage activation syndrome
- Creators
- Sampath PRAHALAD - William S. Rowe Division of Rheumatology, and Division of Pathology, Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United StatesKevin E BOVE - William S. Rowe Division of Rheumatology, and Division of Pathology, Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United StatesDavid DICKENS - William S. Rowe Division of Rheumatology, and Division of Pathology, Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United StatesDaniel J LOVELL - William S. Rowe Division of Rheumatology, and Division of Pathology, Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United StatesAlexei A GROM - William S. Rowe Division of Rheumatology, and Division of Pathology, Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
- Resource Type
- Journal article
- Publication Details
- Journal of rheumatology, Vol.28(9), pp.2120-2124
- Publisher
- Journal of Rheumatology Publishing
- PMID
- 11550985
- ISSN
- 0315-162X
- eISSN
- 1499-2752
- Language
- English
- Date published
- 2001
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984093330002771
Metrics
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