Journal article
Ethanol enhances erbB-mediated migration of human breast cancer cells in culture
Breast cancer research and treatment, Vol.63(1), pp.61-69
2000
DOI: 10.1023/A:1006436315284
PMID: 11079160
Abstract
Growth factor systems (ligands and their receptors) are targets of ethanol toxicity. Inasmuch as alcohol consumption may increase the risk and development of breast cancer, we hypothesize that ethanol enhances cell migration by up-regulating the activities of erbB receptors. Of the three tested breast cancer cell lines that exhibit low invasion capacity (BT-20, MCF-7, and T47D cells), erbB receptors were specifically affected by ethanol only in the T47D cells. Ethanol increased erbB2, erbB3, and erbB4 expression in T47D human breast cancer cells in a concentration-dependent manner. ErbB1 (epidermal growth factor receptor) was unaffected. Heregulin beta 1 (ligand for erbB3 and erbB4) induced a modest increase in the invasion potential of the T47D cells. Ethanol alone also promoted modest invasion by the T47D cells, however, ethanol dramatically increased their heregulin-mediated invasion. Knocking-out erbB2 with an anti-sense oligonucleotide eliminated heregulin beta 1-promoted migration and blocked ethanol-induced chemo-migration. Thus, these data suggest that alcohol may enhance metastasis by altering an erbB system, and pivotally, erbB2.
Details
- Title: Subtitle
- Ethanol enhances erbB-mediated migration of human breast cancer cells in culture
- Creators
- JIA Luo - University of IowaMichael W Miller - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Breast cancer research and treatment, Vol.63(1), pp.61-69
- Publisher
- Springer
- DOI
- 10.1023/A:1006436315284
- PMID
- 11079160
- ISSN
- 0167-6806
- eISSN
- 1573-7217
- Language
- English
- Date published
- 2000
- Academic Unit
- Pathology
- Record Identifier
- 9984186774002771
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