Ethnic differences in cytokine gene polymorphisms: potential implications for cancer development

Jovanny Zabaleta; Barbara G Schneider; Kelli Ryckman; Pleasant F Hooper; M Constanza Camargo; M Blanca Piazuelo; Rosa A Sierra; Elizabeth T H Fontham; Pelayo Correa; Scott M Williams; Augusto C Ochoa

doi:10.1007/s00262-007-0358-4

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Ethnic differences in cytokine gene polymorphisms: potential implications for cancer development

Journal article

Open access

Peer reviewed

Ethnic differences in cytokine gene polymorphisms: potential implications for cancer development

Jovanny Zabaleta, Barbara G Schneider, Kelli Ryckman, Pleasant F Hooper, M Constanza Camargo, M Blanca Piazuelo, Rosa A Sierra, Elizabeth T H Fontham, Pelayo Correa, Scott M Williams, …

Cancer immunology, immunotherapy : CII, Vol.57(1), pp.107-114

01/2008

DOI: 10.1007/s00262-007-0358-4

PMID: 17618436

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https://www.ncbi.nlm.nih.gov/pmc/articles/11031046View

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Abstract

Differences in incidence and outcome of cancer among ethnic groups may be explained by biological and/or socio-economic factors. Genetic variations that affect chronic inflammation, a potentially important risk factor for carcinogenesis, may differ across ethnic groups. Such differences may help explain cancer disparities among these groups. Single nucleotide polymorphisms (SNPs) within cytokine genes can affect cytokine levels and the degree of inflammation. Associations between cancer and some cytokine SNPs have been suggested. However, these have not been consistently replicated among populations, suggesting that SNP function may differ according to ethnicity, or that SNPs alone do not completely account for regulation of inflammation. We examined seven polymorphisms in African-American (n = 294) and Caucasian (n = 299) newborns in Louisiana: IL1B-511C > T, IL1B-31T > C, IL1B + 3954C > T, IL1RN*2, IL10-1082G > A, IL10-592C > A, and TNF-308G > A. African-American newborns had significantly higher frequencies of IL1B-511T, IL1B-31C, IL10-1082A and IL10-592A alleles and complete linkage equilibrium between IL1B + 3954 and IL1B-31. In contrast, IL1B + 3954T, IL1RN*2, and TNF-308A were more frequent in Caucasian newborns and exhibited strong linkage disequilibrium between IL1B + 3954 and IL1B-31. All allelic frequencies were significantly different between groups. We hypothesize that these dissimilarities may contribute to differences in the inflammatory response and cancer incidence and mortality between African-Americans and Caucasians in Louisiana.

European Continental Ancestry Group - genetics

Genetic Predisposition to Disease

Gene Frequency

Humans

African Americans - genetics

Male

European Continental Ancestry Group - ethnology

African Americans - ethnology

Neoplasms - ethnology

Neoplasms - genetics

Inflammation - genetics

Female

Inflammation - ethnology

Polymorphism, Single Nucleotide

Cytokines - genetics

Infant, Newborn

Details

Title: Subtitle: Ethnic differences in cytokine gene polymorphisms: potential implications for cancer development
Creators: Jovanny Zabaleta - Stanley S. Scott Cancer Center, LSUHSC, New Orleans, LA, USA
Barbara G Schneider
Kelli Ryckman
Pleasant F Hooper
M Constanza Camargo
M Blanca Piazuelo
Rosa A Sierra
Elizabeth T H Fontham
Pelayo Correa
Scott M Williams
Augusto C Ochoa
Resource Type: Journal article
Publication Details: Cancer immunology, immunotherapy : CII, Vol.57(1), pp.107-114
DOI: 10.1007/s00262-007-0358-4
PMID: 17618436
NLM abbreviation: Cancer Immunol Immunother
ISSN: 0340-7004
eISSN: 1432-0851
Publisher: Germany
Grant note: P01CA028842 / NCI NIH HHS
Language: English
Date published: 01/2008
Academic Unit: Stead Family Department of Pediatrics; Epidemiology
Record Identifier: 9983996088202771

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