Journal article
Etiologic heterogeneity among non-Hodgkin lymphoma subtypes
Blood, Vol.112(13), pp.5150-5160
12/15/2008
DOI: 10.1182/blood-2008-01-133587
PMCID: PMC2597610
PMID: 18796628
Abstract
Understanding patterns of etiologic commonality and heterogeneity for non-Hodgkin lymphomas may illuminate lymphomagenesis. We present the first systematic comparison of risks by lymphoma subtype for a broad range of putative risk factors in a population-based case-control study, including diffuse large B-cell (DLBCL; N = 416), follicular (N = 318), and marginal zone lymphomas (N = 106), and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL; N = 133). We required at least 2 of 3 analyses to support differences in risk: (1) polytomous logistic regression, (2) homogeneity tests, or (3) dichotomous logistic regression, analyzing all 7 possible pairwise comparisons among the subtypes, corresponding to various groupings by clinical behavior, genetic features, and differentiation. Late birth order and high body mass index (>/= 35) kg/m(2)) increased risk for DLBCL alone. Autoimmune conditions increased risk for marginal zone lymphoma alone. The tumor necrosis factor G-308A polymorphism (rs1800629) increased risks for both DLBCL and marginal zone lymphoma. Exposure to certain dietary heterocyclic amines from meat consumption increased risk for CLL/SLL alone. We observed no significant risk factors for follicular lymphoma alone. These data clearly support both etiologic commonality and heterogeneity for lymphoma subtypes, suggesting that immune dysfunction is of greater etiologic importance for DLBCL and marginal zone lymphoma than for CLL/SLL and follicular lymphoma.
Details
- Title: Subtitle
- Etiologic heterogeneity among non-Hodgkin lymphoma subtypes
- Creators
- Lindsay M Morton - Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Rockville, MD, USA. mortonli@mail.nih.govSophia S WangWendy CozenMartha S LinetNilanjan ChatterjeeScott DavisRichard K SeversonJoanne S ColtMohammad A VasefNathaniel RothmanAaron BlairLeslie BernsteinAmanda J CrossAnneclaire J De RoosEric A EngelsDavid W HeinDeirdre A HillLinda E KelemenUnhee LimCharles F LynchMaryjean SchenkSholom WacholderMary H WardShelia Hoar ZahmStephen J ChanockJames R CerhanPatricia Hartge
- Resource Type
- Journal article
- Publication Details
- Blood, Vol.112(13), pp.5150-5160
- Publisher
- United States
- DOI
- 10.1182/blood-2008-01-133587
- PMID
- 18796628
- PMCID
- PMC2597610
- ISSN
- 0006-4971
- eISSN
- 1528-0020
- Grant note
- N01 PC067008 / NCI NIH HHS N01 PC067010 / NCI NIH HHS N02-PC-71105 / NCI NIH HHS N01-PC-67009 / NCI NIH HHS N01 PC065064 / NCI NIH HHS N01 PC067009 / NCI NIH HHS
- Language
- English
- Date published
- 12/15/2008
- Academic Unit
- Epidemiology
- Record Identifier
- 9983996080902771
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