Ets-1 flips for new partner Pax-5

Miles A Pufall; Barbara J Graves

doi:10.1016/S0969-2126(01)00701-8

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Journal article

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Peer reviewed

Ets-1 flips for new partner Pax-5

Miles A Pufall and Barbara J Graves

Structure (London), Vol.10(1), pp.11-14

01/2002

DOI: 10.1016/S0969-2126(01)00701-8

PMID: 11796106

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Abstract

Protein partnerships provide specificity for transcription factors that display conserved DNA binding properties. The newest Ets-1 partner Pax-5 directs a surprising conformational change that maximizes the protein interface and changes binding site preference.

Protein Structure, Tertiary

Proto-Oncogene Proteins - metabolism

Transcription Factors - chemistry

Protein-Tyrosine Kinases - metabolism

Humans

Models, Molecular

Nuclear Proteins - metabolism

Proto-Oncogene Proteins - genetics

Proto-Oncogene Proteins - chemistry

DNA - metabolism

Transcription Factors - genetics

DNA-Binding Proteins - metabolism

Transcription Factors - metabolism

PAX5 Transcription Factor

Protein-Tyrosine Kinases - genetics

Animals

Protein-Tyrosine Kinases - chemistry

Protein Binding

Proto-Oncogene Protein c-ets-1

Binding Sites

Proto-Oncogene Proteins c-ets

Details

Title: Subtitle: Ets-1 flips for new partner Pax-5
Creators: Miles A Pufall - Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
Barbara J Graves
Resource Type: Journal article
Publication Details: Structure (London), Vol.10(1), pp.11-14
Publisher: United States
DOI: 10.1016/S0969-2126(01)00701-8
PMID: 11796106
ISSN: 0969-2126
eISSN: 1878-4186
Grant note: R01 GM038663 / NIGMS NIH HHS
Language: English
Date published: 01/2002
Academic Unit: Biochemistry and Molecular Biology
Record Identifier: 9984025261002771

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